New naphthoquinones, f13102A and B, from a fungus strain F-13102 |
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Authors: | Yoshimoto Yuya Kawada Manabu Kumagai Hiroyuki Someno Tetsuya Inoue Hiroyuki Kawamura Naoto Isshiki Kunio Ikeda Daishiro |
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Affiliation: | Drug Development Unit, Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan. |
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Abstract: | Deficiency of Fas-mediated apoptosis is one of the mechanisms involved in the immune evasion by tumors. Thus, it might be a practical approach for cancer treatment that Fas-mediated apoptosis in tumor cells is modified by drugs. In the course of screening, we have isolated two new naphthoquinones, f13102A and B, from the culture broth of fungus strain F-13102. Coumpound f13102A sensitizes Fas-resistant human lung adenocarcinoma A549 cells to apoptosis. |
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