Application of multipotent mesenchymal stromal cells from human adipose tissue for compensation of neurological deficiency induced by 3-nitropropionic acid in rats |
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| Authors: | A. V. Kulikov M. S. Stepanova S. L. Stvolinsky R. M. Hudoerkov D. N. Voronkov A. A. Rzhaninova D. V. Goldstein A. A. Boldyrev |
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| Affiliation: | (1) Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia;(2) ReMeTeks Company, Moscow, Russia;(3) Medico-Genetic Research Center, Russian Academy of Medical Sciences, Moscow, Russia;(4) Biomedical Center of M. V. Lomonosov Moscow State University, Moscow, Russia |
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| Abstract: | We evaluated possible therapeutic effect of multipotent mesenchymal stromal cells from human adipose tissue differentiated to neuronal phenotype with retinoic acid on Wistar rats subjected to toxic effect of 3-nitropropionic acid. Transplantation of mesenchymal stromal cells from human adipose tissue considerably decreased neurological symptoms, normalized exploratory activity (open field test) and long-term memory (Morris test), which correlated with normalization of pathomorphological manifestations in the brain. Destructive changes in the caudate nucleus caused by treatment with 3-nitropropionic acid (reduced size of neurons, changes in their shape, and cell edema) tended to decrease under the effect of multipotent mesenchymal stromal cells: the area of neurons increased 2-fold, the cells acquired typical round shape, cell edema decreased. __________ Translated from Kletochnye Tehnologii v Biologii i Meditsine, No. 2, pp. 83–89, April, 2008 |
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| Keywords: | 3-nitropropionic acid multipotent mesenchymal cells long-term memory human adipose tissue |
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