| 葛根素注射液抗心肌缺血实验研究 |
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| 引用本文： | 陈吉萍,张峥,王宏涛. 葛根素注射液抗心肌缺血实验研究[J]. 现代中西医结合杂志, 2011, 20(22): 2749-2750,2753 |
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| 作者姓名： | 陈吉萍 张峥 王宏涛 |
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| 作者单位： | 1. 泸天化公司医院,四川,泸州,646300
2. 泸州医学院附属医院,四川,泸州,646000 |
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| 摘 要： | 目的观察葛根素注射液的抗心肌缺血作用。方法通过葛根素注射液对小鼠常压耐缺氧试验、葛根素注射液二磷酸腺苷(ADP)诱导家兔体外血小板聚集试验、葛根素注射液去甲肾上腺素(NE)诱导大鼠离体动脉环收缩试验,观察葛根素注射液抗心肌缺血的活性。结果小鼠常压耐缺氧试验显示,葛根素注射液各组小鼠平均存活时间明显延长。抗ADP诱导家兔体外血小板聚集试验显示,葛根素注射液对ADP诱导的家兔体外血小板聚集具有较强的抑制作用,与溶媒组比较,有非常显著性差异。抗NE诱导大鼠离体动脉环收缩试验显示,葛根素注射液各浓度均可舒张完整内皮组NE诱导大鼠动脉环,且高浓度组对完整内皮组舒张作用较强。结论葛根素具有抗心肌缺血作用。
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| 关 键 词： | 葛根素注射液 心肌缺血 活性 |
Experimental study of anti myocardial ischemia effect of Puerarin injection |
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| Chen Jiping,Zhang Zheng,Wang Hongtao. Experimental study of anti myocardial ischemia effect of Puerarin injection[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2011, 20(22): 2749-2750,2753 |
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| Authors: | Chen Jiping Zhang Zheng Wang Hongtao |
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| Affiliation: | Chen Jiping1,Zhang Zheng2,Wang Hongtao2(1.The Hospital of Lutianhua Company,Luzhou 646300,Sichuan,China,2.The Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China) |
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| Abstract: | Objective It is to observe the anit-myocardial ischemia effect of Puerarin injection.Methods Anti-myocardial ischemia activities of puerarin injection were observed by normal pressure oxygen deficit tolerance test in rats given Puerarin injection,platelet aggregation test in vitro induced by adenosine diphosphate(ADP) in rabbits given Puerarin injection,excised artery link contraction test induced by noradrenaline(NE) in rats given Puerarin injection.Results Oxygen deficit tolerance test showed that average... |
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| Keywords: | Puerarin injection myocardial ischemia activeness |
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