| 阿昔洛韦棕榈酸酯脂质体凝胶剂的局部透皮试验 |
| |
| 引用本文： | 陈鹰,汤韧,刘辉,彭朝霞,丁明和. 阿昔洛韦棕榈酸酯脂质体凝胶剂的局部透皮试验[J]. 中国医院药学杂志, 2000, 20(6): 324-327 |
| |
| 作者姓名： | 陈鹰 汤韧 刘辉 彭朝霞 丁明和 |
| |
| 作者单位： | 1. 广州军区武汉总医院,湖北武汉,430070
2. 湖北医科大学药学系95级 |
| |
| 摘 要： | 对阿昔洛韦前体药物即阿昔洛韦棕榈酸酯所制得的脂质体胶剂的透皮效果进行初步研究。方法：采用体鼠皮的透皮实验方法，并以阿昔洛韦脂质体凝胶、阿昔洛韦凝胶、阿昔洛韦水溶要昔洛韦软膏剂作比较。结果阿昔洛韦前药脂质体凝胶在皮肤内的滞留多（７４．８２％，透皮率小（１５．６２％）结论：阿昔洛韦棕榈酸酯酯质体凝胶有肩民为高效、安全的新制剂。
|
| 关 键 词： | 阿昔洛韦棕榈酸酯 脂质体凝胶 透皮试验 |
Topical penetration test of acyclovir palmitate in vitro from liposomal gel |
| |
| Cheng Ying,Tang Ren,Liu Hui,et al. Topical penetration test of acyclovir palmitate in vitro from liposomal gel[J]. Chinese Journal of Hospital Pharmacy, 2000, 20(6): 324-327 |
| |
| Authors: | Cheng Ying Tang Ren Liu Hui et al |
| |
| Abstract: | OBJECTIVE:To study the penetrating absorption of acyclovir palmitate liposomal gels.METHODS:The transdermal penetration with excised mice skin of acyclovir ointment were compared.RESULTS:The amount of acyclovir palmitate liposomal gel was much higher in the skin, the penetrating absorption amount and the left were lower than the other preparations.CONCLUSIONS:Acyclovir palmitate liposomal gel will be an effective and low toxical drug for virus dermatopathy. |
| |
| Keywords: | acyclovir palmitate liposomal gels penetrating absorption |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
