| 西洋参茎叶皂甙单体Rb_3对大鼠血流动力学及单钙通道活动的影响 |
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| 引用本文： | 杨世杰,陈霞,李红,钟国赣,张文杰,孙成文,王晓明,江岩. 西洋参茎叶皂甙单体Rb_3对大鼠血流动力学及单钙通道活动的影响[J]. 中国药理学通报, 1995, 0(1) |
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| 作者姓名： | 杨世杰 陈霞 李红 钟国赣 张文杰 孙成文 王晓明 江岩 |
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| 作者单位： | 白求恩医科大学药理教研室，白求恩医科大学生理教研室，白求恩医科大学生理中心实验室 |
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| 摘 要： | 单体皂甙Ｒｂ３自西洋参茎叶皂甙中提取。Ｒｂ３３０ｍｇ·ｋｇ－１可使麻醉大鼠在体心脏的ＭＡＰ，±ｄＰ／ｄｔｍａｘ和ＬＶＳＰ减少。用斑片钳的连细胞电压钳法证明．Ｒｂ３３００ｍｇ·Ｌ－１使Ｌ、Ｂ、Ｔ型钙通道的开放时间缩短、开放概率减少，其作用与异搏定３７．５ｍｇ·Ｌ－１相似，与ＢａｙＫ８６１１５μｍｏｌ·Ｌ－１作用相反。确切地证明Ｒｂ３对钙通道有阻滞作用。
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| 关 键 词： | 西洋参，皂甙，钙通道，斑片钳，血流动力学 |
Influence of panax quinquefolium saponin monomer Rb_3 on hemodynamics and single calcium channel activity in rats |
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| YANG Shi-Jie,CHEN Xia, LI Hong,ZHONG Guo-Gan, et al. Influence of panax quinquefolium saponin monomer Rb_3 on hemodynamics and single calcium channel activity in rats[J]. Chinese Pharmacological Bulletin, 1995, 0(1) |
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| Authors: | YANG Shi-Jie CHEN Xia LI Hong ZHONG Guo-Gan et al |
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| Abstract: | Saponin monomer Rb3 was extracted from the stems and leaves of Panaxquinquefolium.Rb3 30 mg· kg-1 decreased the MAP.±dP/dtmax and LVSP of anaesthetic rat hearts in vivo. Using the cell attached configration of the patch clamp technique,it was demonstrated that Rb3 300 mg· L-1 decreased the open time and the open-state probabillity of L. Band T type calcium channels. The effect was similar to that of verapamil 37.5 mg·L-1 and opposite to that of Bay K8644 5 μmol· L-1. Theresults conclusively prove that Rb3 has blockade effect on calcium chanls. |
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| Keywords: | panax quinquefolium saponin calcium channel patch clamp hemodynamics |
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