| 蜂胶抗诱变作用的实验研究 |
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| 引用本文： | 崔群,王志平,范志涛,韩连堂,李佩贤. 蜂胶抗诱变作用的实验研究[J]. 中国新药杂志, 2005, 14(3): 293-295 |
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| 作者姓名： | 崔群 王志平 范志涛 韩连堂 李佩贤 |
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| 作者单位： | 潍坊医学院卫生学教研室,潍坊,261042 |
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| 基金项目： | 山东省中医药管理局资助项目 |
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| 摘 要： | 目的:探讨蜂胶对环磷酰胺等强诱变剂诱发基因突变的抑制作用.方法:应用Ames试验分别检测蜂胶对环磷酰胺(CP)、叠氮钠(NaN3)、正定霉素(DNR)、2-氨基芴(2-AF)诱发基因突变的抑制作用.并观察蜂胶对CP诱发的小鼠骨髓微核、小鼠胎肝微核损伤的保护作用.结果:蜂胶对CP等4种诱变剂诱发的基因突变均产生强抑制作用,且具有剂量-效应关系.对诱变剂诱发的小鼠骨髓微核和胎肝微核的发生率也分别有中、强度抑制作用.结论:蜂胶具有一定的综合抗诱变作用.
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| 关 键 词： | 蜂胶 诱变剂 基因突变 Ames试验 微核 |
| 文章编号： | 1003-3734(2005)03-0293-03 |
Anti-mutational effects of propolis |
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| CUI Qun,WANG Zhi-ping,FAN Zhi-tao,HAN Lian-tang,LI Pei-xian. Anti-mutational effects of propolis[J]. Chinese Journal of New Drugs, 2005, 14(3): 293-295 |
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| Authors: | CUI Qun WANG Zhi-ping FAN Zhi-tao HAN Lian-tang LI Pei-xian |
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| Abstract: | Objective:To study the effects of propolis against gene mutation induced by powerful mutagens in mice. Methods: Ames tests were used to evaluate the inhibition of porpolis on gene mutation induced by cyclophosphamide (CP), sodium azide (NaN3),daunorubcin (DNR) and 2-aminofluorane (2-AF), respectively. The protection of marrow micronucleus and fetal liver marrow by propolis against CP was investigated. Results:Propolis showed the inhibitory effects on gene mutations induced by 4 mutagens in mice, which had a dependency of dosing,and provided protections of the marrow micronucleus and fetal liver against CP. Conclusion: Propolis exhibits certain anti-genetic mutational effects in mice. |
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| Keywords: | propolis mutagens genes mutation Ames-test micronuclear |
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