|
|||||
|
|
Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas |
|
| Authors: | Kuan-Yin Tseng Min-Huey Chung Huey-Kang Sytwu Horng-Mo Lee Kuan-Yu Chen Chen Chang Chih-Kung Lin Che-Hung Yen Jia-Hong Chen Gu-Jiun Lin Hsin-I Ma Yi-Shian Yeh Da-Tong Ju Ming-Ying Liu Dueng-Yuan Hueng |
| Affiliation: | 1. Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center 325, Sec. 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan, ROC 2. Graduate Institute of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan, ROC 3. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC 9. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC 11. Institute of Pharmaceutical Science and Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan, ROC 4. Department of Medical Laboratory Sciences and Biotechnology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC 5. Institute of Biomedical Science, Academia Sinica, Nankang, Taipei, Taiwan, ROC 6. Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC 7. Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC 8. Division of Hemato-Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC 10. Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Center of Excellence for Cancer Research, Taipei Medical University, Taipei, Taiwan, ROC |
| Abstract: | Prediction of recurrence remains a challenge in histopathological benign/grade I tumors. Osteopontin (OPN) plays important roles in tumorigenesis, invasion, and metastasis of several human cancers. In this study, we investigated OPN protein expression by evaluating the differences between recurrent and non-recurrent histologically benign meningiomas. Thirty-two patients were enrolled, and 23 benign non-recurrent meningiomas and 9 benign recurrent meningiomas were followed for a mean of 34 months after complete surgical resection (Simpson grades I and II). Cytoplasmic OPN staining was evaluated by means of immunohistochemistry (IHC) score and by use of the Allred-8-unit system. We examined clinical biological data, their relationship with tumor recurrence, and the expression of OPN. Our results showed that meningioma recurrence correlated significantly with OPN IHC score (P = 0.001). An OPN Allred score between 0 and 3 was associated with a recurrence-free time of more than 25 months. In comparison, an OPN Allred score from 4 to 8 was indicative of a shorter average recurrence-free time. We concluded that OPN IHC score may play a role in prediction of the recurrence of the grade I meningiomas. Moreover, determination of the OPN Allred score is a reliable, quantitative tool for predicting recurrence-free time in benign meningioma patients. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |