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Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm: a report of two cases |
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| Authors: | Nóra Erős Márta Marschalkó Katalin Balassa Bernadett Hídvégi József Szakonyi Sándor Ilniczky Katalin Borka Attila Kovács Gyula Bottlik Judit Hársing Judit Csomor Ágota Szepesi András Matolcsy Sarolta Kárpáti Judit Demeter |
| Affiliation: | 1. Department of Dermatology, Venerology and Dermatooncology, Faculty of Medicine, Semmelweis University, Mária str. 41, 1085, Budapest, Hungary 2. 1st Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary 3. Department of Neurology, Faculty of Medicine, Semmelweis University, Budapest, Hungary 4. 2nd Department of Pathology, Faculty of Medicine, Semmelweis University, Budapest, Hungary 5. 1st Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, Budapest, Hungary |
| Abstract: | CD4+/CD56+ hematodermic neoplasm, formerly known as blastic NK-cell lymphoma, is an uncommon, aggressive non-Hodgkin’s lymphoma with cutaneous, lymph node, and bone marrow involvement at presentation. The disease is characterized by early leukemic phase; however, central nervous system involvement is rarely reported. Herein we describe two cases of CD4+/CD56+ hematodermic neoplasm with meningeal manifestation. Microscopic analysis and flow cytometry of cerebrospinal fluid proved to be diagnostic; however, imaging studies were not informative. These observations call attention to the possibility of central nervous system involvement, which could be more common than expected previously. Authors recommend routine cerebrospinal fluid analysis and prophylactic intrathecal chemotherapy in patients with this highly aggressive disease. |
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