Improvement of contextual memory by S 24795 in aged mice: comparison with memantine |
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Authors: | Daniel Beracochea Aurelie Boucard Caryn Trocme-Thibierge Philippe Morain |
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Institution: | (1) Centre de Neurosciences Intégratives et Cognitives (CNIC), CNRS UMR 5228, Universités de Bordeaux 1 et 2, Avenue des Facultés, 33405 Talence-Cédex, France;(2) Institut de Recherches Internationales Servier, 6 place des Pléiades, 92415 Courbevoie Cedex, France |
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Abstract: | Results In comparison with 5-month-old mice, 18- to 19-month-old mice exhibited a severe and specific memory impairment in a contextual
serial discrimination (CSD) task involving the learning and remembering of two successive spatial discriminations carried
out on two distinct floors. This impairment was specific, as spatial memory, simultaneously tested on a simple discrimination
(SD) task, was not affected in these aged mice. This deficit was completely reversed by 9-day per os administration of S 24795,
a partial agonist of α7 nicotinic receptors, at either 0.3 or 1.0 mg/kg. Memantine, an NMDA receptor antagonist, also had
a memory-enhancing effect at a dose of 3.0 mg/kg, but not at 0.3 mg/kg.
Conclusions The memory-enhancing effect of S 24795 was due to a strong enhancement of contextual memory as indicated by a decrease in
interference rate, whereas memantine enhanced spatial/semantic memory. S 24795 was more effective than memantine and also
appears to be more specific to flexible forms of memory, one of the first cognitive domains (i.e. episodic memory) affected
in Alzheimer’s disease. |
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Keywords: | Ageing Mice Contextual memory Episodic memory S 24795 Memantine Nicotinic receptors |
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