某儿童医院肺炎链球菌耐药性分析

目的了解某儿童医院肺炎链球菌对常用抗菌药物的耐药情况，以指导临床合理用药。方法对2000—2001年在该院就诊的上呼吸道感染患儿的鼻咽分泌物进行细菌培养；采用K-B纸片及E-test法对分离株进行药物敏感试验。结果分离出肺炎链球菌157株。肺炎链球菌对青霉素的耐药率为59．87％，对头孢呋辛、头孢克洛、红霉素、四环素的耐药率分别为40．77％，56．00％，77．71％，87．90％；对氯霉素仍保持低水平耐药(33．12％)，对阿莫西林／克拉维酸、头孢曲松有很好的敏感性。结论儿童上呼吸道感染的肺炎链球菌耐药形势严峻。

Analysis of antimicrobial resistance of Streptococcus pneumonia in a children''''s hospital

Objective To investigate the antimicrobial resistance of Streptococcus pneumonia (Sp) isolated from children in a children's hospital and to guide the rational drug usage in clinic. Methods Bacteria strains were isolated from the nasopharyngeal secretion of children with upper respiratory tract infection from 2000 to 2001. Antimicrobial susceptibility tests were performed with disk agar diffusion and E-test methods. Results One hundred and fifty-seven strains of Sp were isolated. The resistant rate of Sp to penicillin was 59.87% , the resistant rate to cefuroxine, cefaclor, erythromycin and tetracycline was 40.77% , 56.00% , 77.71% and 87.90% respectively, the resistant rate to chloramphenicol was low ( 33.12% ). The isolates of Sp were susceptible to amoxicillin/clavulanic acid and ceftriaxone. Conclusion Antimicrobial resistance of Sp isolated from children with upper respiratory tract infection in this area is a serious problem.