| HLA配型与肾移植术后早期急性排斥反应的关系 |
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| 引用本文： | 尔秀江,李哲先,薛竹,毕如玫,张玉海,解泽林,马威然,武俊杰. HLA配型与肾移植术后早期急性排斥反应的关系[J]. 中华器官移植杂志, 2000, 21(1): 6-7 |
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| 作者姓名： | 尔秀江 李哲先 薛竹 毕如玫 张玉海 解泽林 马威然 武俊杰 |
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| 作者单位： | 首都医科大学附属北京友谊医院泌尿科,北京,100050 |
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| 摘 要： | 目的 研究ＨＬＡ配型与尸体肾移植术后早期急性排斥反应的关系。方法 将２６２例尸体肾移植受者按ＨＬＡ配型的误配率（ＭＭ）进行分组，统计各组术后１～２个月内急性排斥反应的发生次数。结果 当ＭＭ〉３时，若接受的器官ＨＬＡ抗原／基因为可接受性，术后急性排斥反应的发生率为１６．４％；若供体器官ＨＬＡ抗原／基因具免疫原性，则急性排斥反应的发生率为３３．１％，两者比较，Ｐ〈０．０５。结论 供受者间ＨＬＡ配型越好
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| 关 键 词： | 肾移植 HLA抗原 排斥反应 |
| 修稿时间： | 1998-06-30 |
The relationship between HLA typing and early rejection after cadaver donor kidney transplantation |
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| ER Xiujiang,LI Zhexian,XUE Zhu,et al.. The relationship between HLA typing and early rejection after cadaver donor kidney transplantation[J]. Chinese Journal of Organ Transplantation, 2000, 21(1): 6-7 |
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| Authors: | ER Xiujiang LI Zhexian XUE Zhu et al. |
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| Affiliation: | ER Xiujiang,LI Zhexian,XUE Zhu,et al. Department of Urology,Beijing Friendship Hospital,Beijing 100050,China |
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| Abstract: | Objective To study the relationship between HLA typing and early rejection after cadaver donor kidney transplantation. Methods The 262 recipients undergoing cadaver donor kidney transplantation were randomly grouped in terms of the HLA mismatching (MM) of donors with permissible antigen or immunogenic antigen. The incidence of early rejection in 1 to 2 months after operation was analyzed. Results When the MM>3, if the received organ HLA antigen/gene was permissible, the incidence of postoperative acute rejection was 16.4% ; but if the donor organ HLA antigen/gene was immunogenic, the incidence was 33.1% ( P < 0.05 ). Conclusion The better HLA matching of donor recipient, the fewer influence of HLA mismatching with permissible antigen or immunogenic antigen on early rejection. |
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| Keywords: | Kidney transplantation HLA antigens Graft rejection |
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