RATE OF FORMATION OF NORPETHIDINE FROM PETHIDINE |
| |
| Authors: | AUSTIN K L; STAPLETON J V; MATHER L E |
| |
| Institution: | Department of Anaesthesia and Intensive Care, Flinders Medical Centre Bedford Park, S.A., 5042, Australia
*Present address: C.S.I.R.O. Division of Computing Research Canberra, A.C.T. 2601, Australia |
| |
| Abstract: | The concentrations of norpethidine in blood were determinedin patients recovering from abdominal surgery following bothmultiple i.m. injections (i.m. group) and the i.v. infusion(i.v. group) of pethidine. The rate of administration of pethidineaveraged 25mg h–1 in both groups. Concentrations of norpethidinewere generally small compared with those of pethidine althoughthe ratio of norpethidine to pethidine concentrations increasedsteadily over the 2 days studied. The rate of increase of bloodconcentration of norpethidine was 0.013 µg ml–1h–1 in both groups of patients. No significant toxic effectswere observed. |
| |
| Keywords: | |
| 本文献已被 Oxford 等数据库收录！ |
|
