刺五加叶皂苷对急性心肌梗塞大鼠心室重构的作用

目的：通过大鼠急性心肌梗塞心室重构模型观察刺五加叶皂苷（ASS）对急性心肌梗塞大鼠心室重构的作用。方法：大鼠结扎左冠状动脉前降支造成急性心肌梗塞心室重构模型，同时应用ASS，给药4周后测定心室重构大鼠血液动力学、生化学及形态学参数。结果： ASS对急性心肌梗塞心室重构大鼠，能明显升高左心室内压最大上升和下降速率（±dp/dtmax）及其校正值（±dp/dtmax/LVSP），降低左心室舒张末压（LVEDP），亦能明显降低左心室容积(LVV)、左心室长轴(LVLA)长度、左心室短轴(LVSA)长度、左心室绝对重量(LVAW)、左心室相对重量(LVRW)，但对右心室绝对重量(RVAW)、右心室相对重量(RVRW)、心率(HR)、左心室收缩压（LVSP）、平均动脉压（MAP）及体重(BW)均无明显影响。ASS可明显降低血清脂质过氧化物 (LPO)及心肌血管紧张素Ⅱ(AngⅡ)和肾上腺素(E) 含量，提高超氧物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)活性。结论：ASS能有效抑制急性心肌梗塞大鼠的心室重构。

Effects of Acanthopanax senticosus saponins on ventricular remodeling in rats with acute myocardial infarction

Objective To investigate effects of Acanthopanax senticosus saponins (ASS) on ventricular remodeling in rats with acute myocardial infarction. Methods The myocardial infarct model was induced by left anterior descending coronary occulusion in rats. After 4 weeks of treatment by ASS, hemodynamic changes, biochemical analysis and morphological parameters were determined in ventricular remodeling rats. Results The maximum left ventricular presure rising and dropping rates (±dp/dt max ) and their left ventricular systolic pressure corrected values(±dp/dt max /LVSP) were increased significantly. The left ventricular end diastolic pressure (LVEDP), the left ventricular volume (LVV), the left ventricular long and short axis(LVLA and LVSA), the left ventricular absolute and relative weight (LVAW and LVRW) were reduced significantly, but there were no significant influences on the right ventricular absolute and relative weight (RVAW and RVRW), the heart rate (HR), the left ventricular systolic pressure (LVSP), mean artery pressure (MAP) and body weight (BW). In addition, the serum lipid peroxidation (LPO) content, myocardial angiotensin Ⅱ (AngⅡ) and epinephrine (E) contents were declined, superoxide dismutase (SOD) and glutathione peroxidase (GSH Px) activities were increased markedly. Conclusion ASS can prevent and treat ventricular remodeling after myocardial infarction in rats efficiently.