Plasma Histamine After Methacholine, Allergen, and Aspirin Challenges |
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Authors: | M. Kinsella H. Salari H. Chan K. S. Tse M. Chan-Yeung |
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Affiliation: | a Respiratory Division Department of Medicine, University of British Columbia, British Columbia, Canadab Vancouver General Hospital Vancouver, British Columbia, Canada |
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Abstract: | Plasma histamine levels were measured by radio-enzymatic technique in seven patients following 10 challenges: five methacholine challenge tests, four antigen inhalation challenge tests, and one oral aspirin challenge test. Baseline plasma histamine was the same in all patients except in the aspirin-challenged patient, who had a higher baseline histamine level. There was no statistical change in the level of histamine throughout the test in either the methacholine-challenged or the antigen-challenged patients, whereas there was a marked increase in histamine levels in the aspirin challenged patient. A possible explanation is that methacholine and antigen are inhaled and therefore have primarily local effects on the lung, whereas oral aspirin has a systemic effect with consequently systemic changes in histamine which are detectable as changes in plasma level. |
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