舒心宁胶囊质量标准的研究

目的:建立舒心宁胶囊质量标准。方法:用薄层色谱法鉴别方中的川芎、丹参;以十八烷基键合硅胶为填充剂,甲醇-水(28:72)为流动相,检测波长为230nm,采用高效液相色谱法测定芍药苷的含量。结果:薄层色谱斑点明显,阴性无干扰。芍药苷在20～140μg范围内线性关系良好(r=1.0000),方法平均回收率为99.47%,RSD为1.27%。结论:本方法具有简便易行、重现性好、结果可靠、专属性强等特点,适用于舒心宁胶囊的质量控制。

Study on Quality Standard of Shuxinning Capsules

Objective:To establish the standard for the quality control of Shuxinning capsules.Methods:Ligusticum wallichii and Salvia were identified qualititatively by thin-layer chromatography(TLC). Paeoniflovin in Shuxinning capsules was determined by HPLC,the chromatographic conditions were as follows:Octadecyl silane were used as the chromatographic column filler,methol-water(28:72)was used as the mobile phase,the detection wavelength was 230 nm.Results:The TLC spots were highly clear without the interference of negative control. The calibration curve for paeoniflovin was linear(r =1.0000)in the range of 20μg-140μg,and the mean recovery was 99.47%,RSD was 1.27%.Conclusion:This method is accurate,simple,sensitive and reliable and it can be used for the quality control of Shuxinning capsules.