舍曲林和氯丙咪嗪对强迫症患者疗效和认知功能的影响

目的比较舍曲林与氯丙咪嗪的治疗对强迫症患者疗效和认知功能的影响。方法 80例强迫症患者配对分成两组。分别接受舍曲林和氯丙咪嗪治疗。采用Yale-Brown强迫量表(Y-BOCS)、划消测验、韦氏记忆量表、威斯康星卡片分类测验评定两组患者治疗前后成绩。结果①与治疗前相比,舍曲林组和氯丙咪嗪组Y-BOCS总分、强迫观念和强迫行为评分差异均有统计学意义(t=3.541～9.658,P<0.01);舍曲林组和氯丙咪嗪组相比,治疗前和治疗后上述评分均无统计学意义(t=0.654～1.241,P>0.05);②治疗后,舍曲林组划消测验、记忆指标、WCST各项测验成绩与氯丙咪嗪组比较均存在显著性差异(t=4.257～8.645,P<0.01)。结论舍曲林和氯丙咪嗪对强迫症的治疗均有效。舍曲林对强迫症认知功能的改善作用显著优于氯丙咪嗪。

The effect and Cognition Function Change of Patients with Obsession-compulsion Disorder before and after Sertraline and Chlorimipramine Treatment

Objective To compare the effect and cognition function change of patients with obsession-compulsion disorder before and after sertraline and chlorimipramine treatment.Methods A total of 80 patients were parallelly divided into two groups receiving sertraline and chlorimipramine respectively.Using Y-BOCS,dashes away test,WMS-R and Wisconsin Card Sorting Test as research tools to compare the symptom and cognition function of the two groups before and after 8 week treatment.Results ①After the treatment,the patients had better scores of Y-BOCS obsession ideal and compulsion behavior.There were no significant differences of the scores between sertraline group and chlorimipramine group(t=3.541～9.658,P<0.01).②After the treatment,there were significant differences between the sertraline group and the chlorimipramine group in the scores of dashes away test and WMS-R and Wisconsin Card Sorting Test(t=4.257～8.645,P<0.01).Conclusion The sertraline has the same effect as the chlorimipramine in the obsession-compulsion patients.In the cognitive function,sertraline improved significantly better than chlorimipramine.