Molecular cloning and characterization of Plasmodium falciparum transportin |
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Authors: | Xu Xuenian Yamasaki Hiroshi Feng Zheng Aoki Takashi |
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Affiliation: | Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai, People's Republic of China. |
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Abstract: | A cDNA encoding transportin, a protein involved in the nuclear import of M9 nuclear localization signal-bearing proteins, has been cloned from the malaria parasite Plasmodium falciparum. The complete cDNA consists of 3,667 bp encoding 1,136 amino acid residues. Amino acid sequence analysis revealed that Ran-GTP and M9 binding domains are highly conserved in P. falciparum, suggesting that the transportin-mediated nuclear transport pathway exists in this protozoan parasite. Southern blot analysis revealed that the transportin gene exists as a single copy in the malarial genome. |
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