重症肌无力血清乙酰胆碱受体抗体的阳性率及其影响因素

采用ABC-ELISA法检测162例重症肌无力患者的224份血清标本,100例正常人和78例其他疾病病人的血清中AchRab。重症肌无力病人的抗体阳性率为80.2％,其中单纯眼肌型63.1％,脊髓肌型90.0％,延髓肌型93.8％和全身肌型91.5％。合并胸腺瘤的阳性率为83.3％,与全组阳性率无显著性差异。激素和血浆交换治疗均未影响抗体阳性结果。随访观察表明,重症肌无力病人的AchRab阳性率与疾病严重程度不成线性相关。我们认为,AchRab滴度虽然与临床状况不相关,但在重症肌无力的诊断和自身免疫病因的研究中,仍是一项重要参数。

The positive percentage of antibodies to acetylcholine receptor and its significance in myasthenia gravis.

Two hundred and twenty-four samples of sera from 162 patients with myasthenia gravis (MG) were detected for antibodies to Acety Choline receptor (AchR) by Avidin-Biotin complex enzyme linked immunoabsorbent assay (ABC - ELISA). The results showed that the positive percentage of . the antibodies to AchR was 80. 2% for MG, 27% for other diseases, none in healthy subjects. The antibodies level in simple ocular type of MG was significantly lower than that in other types of MG patients. It was also found that neither plasmaphoresis nor steroid treatment can influent the positive rate of the antibodies to AchR. We consisdered that the antibodies to AchR in MG were very important parameters for diagnosis and autoimmune pathogenetic studies, although there was no correlation between AchRab and clinical status.