TLRs在过敏性炎症反应中的作用

卫生学假说(Hygienehypothesis)认为幼儿及青少年时期的感染能驱动免疫系统的Th细胞偏向分化成Th1型,而远离与过敏有关的Th2型。虽然这一看法仍有许多疑点与争议,但过敏与感染存在着某种联系已被认可。Toll样受体是机体识别病原微生物的重要模式识别分子,近年来发现TLRs信号可能通过参与诱导产生Th1和/或Th2型细胞因子调节过敏性炎症。

The Effect of TLRs in Allergig Inflannation Reaction

Hygiene hypothesis is the idea that exposure to specific infection drives the Th in infancy/childhood maturing towards a Th1 phenotype, and away from the Th2 phenotype associated with atopy. Allergy and infection must have some association, although it still provokes much debate. Toll like receptors(TLRs) are important pattern recognition molecules for human body to recognize pathogenic microorganism. In recent years,it was found that TLR signaling can modulate allergic inflammatory disease by inducing Th1 and/or Th2 phenotype cytokines. In this article the key roles of TLR and some related molecules participating in allergic reaction were reviewed.