| RP-HPLC法测定安坤颗粒中阿魏酸的含量 |
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| 引用本文： | 肖智朋.RP-HPLC法测定安坤颗粒中阿魏酸的含量[J].中国药师,2009,12(10):1389-1390. |
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| 作者姓名： | 肖智朋 |
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| 作者单位： | 怀化市第一人民医院,湖南怀化,418000 |
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| 摘 要： | 目的：建立安坤颗粒中阿魏酸的含量测定方法。方法：采用Dikma Diamonsil C18色谱柱（250mm×4．6mm，5μm）；流动相：乙腈-0．085％磷酸（20：80）；流速：1．0ml·min^-1；柱温：35℃；检测波长：316nm。结果：阿魏酸进样量在0．0527～1．6858μg范围内与峰面积呈良好线性关系（r=0．9996），平均加样回收率为98．28％（RSD=1．03％，n=9）。结论：本法快速、简便、准确，可作为该制剂的质量控制的方法。
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| 关 键 词： | 反相高效液相色谱法 安坤颗粒 阿魏酸 |
Determination of Ferulic Acid in Ankun Granules by RP-HPLC |
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| Xiao Zhipeng.Determination of Ferulic Acid in Ankun Granules by RP-HPLC[J].China Pharmacist,2009,12(10):1389-1390. |
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| Authors: | Xiao Zhipeng |
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| Institution: | Xiao Zhipeng (First People＇s Hospital of Huaihua City, Huan Huaihua 418000,China) |
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| Abstract: | Objective： To establish a method for the detemination of ferulic acid in Ankun granules. Method： A Dikma Diamonsil Cls column（250mm×4.6mm,5μm） was applied, acetonitrile and 0. 085% phosphate acid（20： 80） was used as the mobile phase, the flow rate was 1.0 ml·min^-1 , the column temperature was at 35℃ and the detection wavelength was at 316nm. Result： The linear range of ferulic acid was 0. 052 7 - 1. 685 8 μg, the average recovery was 98.28 % （ RSD = 1.03 % , n = 9）. Conclusion： The method is rapid, simple and accurate, and can be used to control the quality of this preparation. |
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| Keywords: | RP-HPLC Ankun granules Ferulic acid |
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