Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss |
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Authors: | Yong-qiang Yu Huai-an Yang Ming Xiao Jing-wei Wang Dong-yan Huang Yagesh Bhambhani Lyn Sonnenberg Brenda Clark Yuan-zhe Jin Wei-neng Fu Jie Zhang Qian Yu Xue-ting Liang Ming Zhang |
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Affiliation: | 1. Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine,University of Alberta, Edmonton, AB T6G 2B7, Canada;2. Department of Otolaryngology, The First Affiliated Hospital,China Medical University, Shenyang 110001, China;3. Department of Surgery, The People's Hospital of Liaoning Province,Shenyang 110016, China;4. Department of Obstetrics and Gynecology,University of Alberta, Edmonton, AB T6G 2B7, Canada;5. Department of Otolaryngology-Head & Neck Surgery,PLA General Hospital, Beijing 100853, China;6. Department of Developmental Pediatrics,Glenrose Rehabilitation Hospital, Edmonton, AB T5G 0B7, Canada |
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Abstract: | In this article, the mechanism of inheritance behind inherited hearing loss and genetic susceptibility in noise-induced hearing loss are reviewed. Conventional treatments for sensorineural hearing loss (SNHL), i.e. hearing aid and cochlear implant, are effective for some cases, but not without limitations. For example, they provide little benefit for patients of profound SNHL or neural hearing loss, especially when the hearing loss is in poor dynamic range and with low frequency resolution. We emphasize the most recent evidence-based treatment in this field, which includes gene therapy and allotransplantation of stem cells. Their promising results have shown that they might be options of treatment for profound SNHL and neural hearing loss. Although some treatments are still at the experimental stage, it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application. |
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Keywords: | inherited hearing loss inheritance noise-induced hearing loss genetic susceptibility gene therapy stem cell |
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