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| 降脂利肝颗粒对小鼠急性肝损伤的保护作用 | |
| 引用本文： | 卞晓岚,沈龙海,余自成,周光兴,翟青. 降脂利肝颗粒对小鼠急性肝损伤的保护作用[J]. 药学服务与研究, 2008, 8(5) |
| 作者姓名： | 卞晓岚 沈龙海 余自成 周光兴 翟青 |
| 作者单位： | 1. 上海交通大学医学院附属瑞金医院药剂科,上海,200025 2. 上海医药工业研究院药理研究室,上海,200437 3. 复旦大学上海医学院实验动物科学部病理室,上海,20032 |
| 摘 要： | 目的：研究降脂利肝颗粒对急性肝损伤小鼠的保护作用。方法：以四氯化碳（CCl4）诱导急性肝损伤制作肝损伤小鼠模型，分别给予低（100mg／kg）、中（300mg／kg）、高（900mg／kg）3个剂量的降脂利肝颗粒浸膏，以联苯双酯（200mg／kg）为阳性对照药物，检测血清中丙氨酸氨基转移酶（ALT）和门冬氨酸氨基转移酶（AST）的水平，并进行病理学检查。结果：与模型对照组比较，降脂利肝颗粒浸膏低、中、高3个剂量组ALT和AST水平显著降低（P〈0．05）。降脂利肝颗粒浸膏低剂量组降低ALT水平的作用不如阳性对照联苯双酯组明显，中、高剂量组作用与联苯双酯组相似。降脂利肝颗粒浸膏低、中、高3个剂量组均能减轻肝组织病理损伤程度。结论：降脂利肝颗粒对小鼠急性肝损伤具有较好的保护作用。 |
| 关 键 词： | 降脂利肝颗粒 急性肝损伤 膏剂 小鼠 |
Protective effects of Jiangzhiligan granules againstacute liver injury in mice |
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| BIAN Xiao-lan,SHEN Long-hai,YU Zi-cheng,ZHOU Guang-xing,ZHAI Qing. Protective effects of Jiangzhiligan granules againstacute liver injury in mice[J]. Pharmaceutical Care and Research, 2008, 8(5) | |
| Authors: | BIAN Xiao-lan SHEN Long-hai YU Zi-cheng ZHOU Guang-xing ZHAI Qing |
| Affiliation: | BIAN Xiao-lan1,SHEN Long-hai2,YU Zi-cheng1,ZHOU Guang-xing3,ZHAI Qing1(1.Department of Pharmacy,Ruijin Hospital affiliated to Shanghai Jiaotong University,Shanghai 200025,China,2.Department of Pharmacology,Shanghai Institute of Pharmaceutical Industry,Shanghai 200437,3.Department of Pathology,Experimental Animal Branch,Shanghai Medical College,Fudan University,Shanghai 200032,China) |
| Abstract: | Objective:To study the protective effects of Jiangzhiligan granules against acute liver injury in mice.Methods: The serum levels of alanine aminotransferase(ALT) and asparate aminotransferase(AST) were measured in mice with acute liver injury induced by carbon tetrachloride(CCl4) after oral administration of low(100 mg/kg),medium(300 mg/kg) and high(900 mg/kg) dosage of Jiangzhiligan granules.Biphenyldicarboxylate(200 mg/kg) was used as a positive control.The patholo-gical examination of the liver specimen ... |
| Keywords: | Jiangzhiligan granules acute liver injury extract mice |
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