| 甲砜霉素甘氨酸酯盐酸盐的合成 |
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| 引用本文： | 孙逊,董纪昌,俞新华. 甲砜霉素甘氨酸酯盐酸盐的合成[J]. 中国药物化学杂志, 1998, 0(4) |
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| 作者姓名： | 孙逊 董纪昌 俞新华 |
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| 作者单位： | 上海医科大学药学院有机化学教研室 |
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| 摘 要： | 甲砜霉素甘氨酸酯盐酸盐增加了甲砜霉素的水溶性，可制成注射剂．其合成工艺是以甲砜霉素和氯乙酰氯为起始原料，经酰化、环六亚甲基（又称乌洛托品）成盐、水解及酸化成盐，合成了甲砜霉素甘氨酸酯盐酸盐
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| 关 键 词： | 甲砜霉素；甲砜霉素甘氨酸酯盐酸盐；酰化；缩合 |
Research for Synthesis of Thiamphenicol Glycinate Hydrochloride |
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| Sun Xun,Dong Jichang,Yu Xinhua. Research for Synthesis of Thiamphenicol Glycinate Hydrochloride[J]. Chinese Journal of Medicinal Chemistry, 1998, 0(4) |
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| Authors: | Sun Xun Dong Jichang Yu Xinhua |
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| Abstract: | Thiamphenicol glycinate hydrochloride may improve the solubility of thiamphenicol and can be made into an injection.By the route of synthesis thiamphenicol glycinate hydrochloride from thiamphenicol and chloroacetyl chloride via the acylation,the salt with hexamethylenetetramine in acetonitrile and hydrolysis of salt in ethanol and concentrated hydrochloric acid,was synthesized. |
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| Keywords: | thiamphenicol thiamphenicol glycinate hydrochloride acylation condensation |
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