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进展期肺癌肿瘤标记物临床应用价值
引用本文:宋丽华,宋现让,张锡芹,齐洁琳,张品良,刘美芹,田禾,刘蒲香. 进展期肺癌肿瘤标记物临床应用价值[J]. 中华肿瘤防治杂志, 2003, 10(3): 272-275
作者姓名:宋丽华  宋现让  张锡芹  齐洁琳  张品良  刘美芹  田禾  刘蒲香
作者单位:山东省肿瘤防治研究院,山东,济南,250117
摘    要:目的 :评价进展期肺癌患者血清癌胚抗原 (CEA)、神经元特异性烯醇化酶 (NSE)、细胞角蛋白19片段 (CYFRA2 1 1)水平在肺癌诊断、确定病理类型和病情评估方面的临床价值。方法 :采用生物素酶免法测定 79例ⅢA、ⅢB、Ⅳ期原发性肺癌和术后复发或转移患者血清CEA、NSE、CYFRA2 1 1水平。结果 :79例进展期肺癌患者治疗前CEA、NSE、CYFRA2 1 1明显高于正常对照组。 3项联合检测阳性率达 97 5 %。鳞癌组、腺癌组和小细胞未分化癌组之间肿瘤标记物水平差异有显著性。CEA水平以腺癌组最高 ,NSE水平以小细胞未分化癌组最高 ,CYFRA2 1 1水平以鳞癌组最高。化疗有效者肿瘤标记物水平降低 ,病情进展和肿瘤转移患者则升高。结论 :CEA、NSE、CYFRA2 1 1联合用于肺癌的诊断有极高的特异性和敏感性 ,NSE CYFRA2 1 1与肺癌的病理类型有很好的相关性 ,为无法做病理学检查的患者的治疗提供支持 ,此外在病情监测和疗效判断方面可为临床提供有价值的资料

关 键 词:肺肿瘤/诊断  磷酸丙酮酸水合酶/血液  癌胚抗原/血液  角蛋白/血液  肿瘤标记  生物学
文章编号:1009-4571(2003)03-0272-04
修稿时间:2002-03-13

Value of CEA,NSE and CYFRA21-1 in Patients with Advanced Lung Carcinoma
SONG Li hua,SONG Xian rang,ZHANG Xi qin,et al.. Value of CEA,NSE and CYFRA21-1 in Patients with Advanced Lung Carcinoma[J]. Chinese Journal of Cancer Prevention and Treatment, 2003, 10(3): 272-275
Authors:SONG Li hua  SONG Xian rang  ZHANG Xi qin  et al.
Affiliation:SONG Li hua,SONG Xian rang,ZHANG Xi qin,et al.Shandong Tumor Hospital & Institute,Jinan 250117,China
Abstract:Objective To evaluate the value of CEA,NSE and CYFRA21 1 in patients with advanced lung carcinoma.Methods These tumor markers in serum were measured in 79 patients with advanced lung carcinoma using biotin strepavidin EIA.Results The level of CEA,NSE and CYFRA21 1 in patients with advanced lung carcinoma before treatment was significantly higher than that in controls.Single analysis showed that CEA for adenocarcinoma,NSE for small cell lung cancer and CYFRA21 1 for squamous carcinoma had higher positive rate.Combination of these tumor markers increased sensitivity.After chemotherapy (curative effects:CR PR),the serum levels of the markers in patients with object remission was decreased significantly.Conclusions Measurement of CEA,NSE and CYFRA21 1 in serum provides useful information for diagnosis and evaluation of disease extent in patients with advanced lung cancer.The ratio of NSE to CYFRA21 1 is a wonderful index correlated to the pathologic type.The changement of biomarkers serum level reflects the effects of chemotherapy. China J Cancer Prev Treat,2003,10(3):272-275
Keywords:lung neoplasms/diagnosis  phosphopyruvate hydratase/blood  carcinoembryonic antigen/blood  keratin/blood  tumor markers  biology
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