In Vitro Susceptibility to Gemifloxacin and Trovafloxacin of Streptococcus pneumoniae Strains Exhibiting Decreased Susceptibility to Ciprofloxacin |
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Authors: | F Fuentes M J Giménez F Marco L Alou L Aguilar J Prieto |
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Institution: | (1) Microbiology Department, School of Medicine, Universidad Complutense, Avenida Complutense s/n, 28040 Madrid, Spain, ES;(2) Medical Department, SmithKline Beecham Pharmaceuticals, Valle de la Fuenfría 3, 28034 Madrid, Spain e-mail: lorenzo.aguilar-alfaro@sb.com, ES;(3) Microbiology Department, Hospital Clinic i Provincial, Villarroel 170, 08036 Barcelona, Spain, ES |
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Abstract: | The in vitro susceptibility to trovafloxacin and gemifloxacin of Streptococcus pneumoniae strains exhibiting decreased susceptibility to ciprofloxacin (MIC ≥2 μg/ml; 30 strains with intermediate resistance MIC
2 μg/ml] and 43 strains with complete resistance MIC ≥4 μg/ml]) was determined. Seventy-three strains collected in a surveillance
study carried out from May 1996 to April 1997 in Spain (prior to commercialisation of trovafloxacin and gemifloxacin) from
patients with respiratory tract infections were tested. The antibacterial activity of gemifloxacin was affected to a lesser
extent than that of trovafloxacin by the increase in the MIC of ciprofloxacin, with gemifloxacin showing significantly (P≤0.001) better antibacterial activity than trovafloxacin in all ciprofloxacin MIC categories (MIC50/MIC90 values of 0.015/0.03,
0.015/0.06, 0.03/0.06 and 0.12/0.25 μg/ml for gemifloxacin vs 0.12/0.12, 0.12/1, 0.25/0.5 and 2/4 μg/ml for trovafloxacin
in the 2, 4, 8 and ≥16 μg/ml ciprofloxacin MIC categories, respectively). Nine (12.3%) of these 73 strains exhibited decreased
susceptibility to trovafloxacin (≥2 μg/ml), whereas all strains were inhibited by 0.25 μg/ml of gemifloxacin. |
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