| Snail和N-cadherin在乳腺浸润性导管癌中的表达 |
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| 引用本文： | 曹莉,熊正文,黄勇,韩亚伟,苏红,张华东,李伟.Snail和N-cadherin在乳腺浸润性导管癌中的表达[J].华北国防医药,2013(9):18-20,24. |
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| 作者姓名： | 曹莉 熊正文 黄勇 韩亚伟 苏红 张华东 李伟 |
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| 作者单位： | [1]解放军251医院病理科河北张家口,河北张家口075000 [2]河北北方学院,河北张家口075000 |
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| 基金项目： | 全军医学科学研究“十二五”计划课题（01MB093） |
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| 摘 要： | 目的 探讨Snail和N-cadherin在乳腺浸润性导管癌中的表达及其临床意义.方法 采用免疫组化染色法（SP法）检测80例乳腺浸润性导管癌、30例乳腺导管内癌和30例乳腺普通型增生组织中Snail与N-cadherin的表达.结果 乳腺浸润性导管癌中Snail和N-cadherin阳性表达率均显著高于乳腺导管内癌与乳腺普通型增生（P＜0.01）;Snail和N-cadherin在乳腺浸润性导管癌表达与淋巴结转移、TNM分期有关（P＜0.01）;Snail和N-cadherin在乳腺浸润性导管癌中表达呈正相关（r=0.36,P＜0.01）.结论 Snail和N-cadherin在乳腺浸润性导管癌中的过表达参与乳腺癌发生、发展以及浸润转移.
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| 关 键 词： | 乳腺肿瘤 癌 导管内 浸润性 锌指转录因子 神经型钙黏附蛋白 免疫组化 |
Expression of Snail and N-cadherin protein in Invasive Ductal Carcinoma of Mammary Glands |
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| CAO Li,XIONG Zheng-wen,HUANG Yong,HAN Ya-wei,SU Hong,ZHANG Hua-dong,LI Wei.Expression of Snail and N-cadherin protein in Invasive Ductal Carcinoma of Mammary Glands[J].Medical Journal of Beijing Military Region,2013(9):18-20,24. |
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| Authors: | CAO Li XIONG Zheng-wen HUANG Yong HAN Ya-wei SU Hong ZHANG Hua-dong LI Wei |
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| Institution: | 1. Depart- ment of Pathology, 251 Hospital of PLA, Zhangjiakou, Hebei 075000, China; 2. Hebei North University, Zhangjiakou, Hebei 075000, China) |
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| Abstract: | Objective To explore expressions and clinical significance of Snail and neurologic type of cadherin （N-cadherin） in invasive ductal carcinoma of mammary glands. Methods Expressions of Snail and N-cadherin were detected in 80 patients with invasive ductal carcinoma, 30 patients with intraductal breast carcinoma and 30 patients with usual ductal hyperplasia by immunohistostaining method. Results The positive expression rates of Snail and N-cadherin in invasive ductal carcinoma were significantly higher than those in intraductal breast carcinoma and usual ductal hyperplasia respectively （P 〈 0. 01 ） ; expressions of Snail and N-cadherin in invasive ductal carcinoma related to lymphatic metastasis and TNM stages （ P 〈 0.01 ） ; and there was a positive correlation between expressions of Snail and N-cadherin （ r = 0.36,P 〈 0. 01 ）. Conclusion The overexpressions of Snail and N-cadherin may be more valuable in diagnosis of occurrence, development, infiltration and metastasis of breast cancer. |
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| Keywords: | Breast neoplasm Carcinoma intraductal invasion Snail Neurologic type of cadherin Immuno-histochemistry |
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