雪莲黄酮对大鼠创伤性脑水肿的治疗作用及其机制的初步研究

目的研究雪莲黄酮对大鼠创伤性脑水肿的治疗作用及其机制。方法采用液压冲击法制作大鼠脑创伤模型,用雪莲黄酮注射液进行治疗。治疗后不同时间取伤灶及其周围脑组织进行含水量和与脂质过氧化有关的一些指标进行检测。结果脑创伤后6h、24h及3d伤灶及其周围脑组织中含水量及丙二醛含量明显增加(P<0.01),而超氧化物岐化酶含量明显减少(P<0.01),但雪莲黄酮能逆转上述变化。结论雪莲黄酮对大鼠创伤性脑水肿有一定的治疗作用,作用机制可能与其抗脂质过氧化作用有关。

Prelimmary Study of Curative Effect of Xuelianhuangtong on Brain Edema after Traumatic Brain Injury and Its Mechanism in Rats

Objective To study the curative effect of Xuelianhuangtong on brain edema after traumatic brain injury (TBI) in rats and its mechanisms. Methods The model of TBI in rats was established by fluid percussion impacting. Xuelianhuangtong injection was intraperitoneally used as therapy. Water content, malondialdehyde (MDA) and superoxide dismutase (SOD) in the injured brain tissues were determined. Results At the 6th and 24th hours, and on the 3rd day after the brain injury, in the injured brain tissue the water content and MDA content significantly increased (P<0.05), and the activity of SOD was significantly reduced (P<0.01). The above-mentioned changes in the water content, MDA and SOD could be reversed by intraperitoneal injection of Xuelianhuangtong. Conclusion The curative effect of Xuelianhuangtong on the posttramautic brain edema has been proved and is due to its resistance to lipid peroxidation.