应用丙泊酚实施无痛胃镜的临床研究

目的：观察丙泊酚静脉麻醉在无痛胃镜检查中的应用效果及安全性。方法：1 031例胃镜检查患者均采用微量泵持续静注丙泊酚,观察患者麻醉前（术前）、麻醉中（术中）及麻醉后（术后）的血压、血氧饱和度及心率变化及术中不良反应、清醒时间、舒适程度等。结果：收缩压及舒张压术前组、术中组、术后组之间的差别有显著性统计学意义。术中收缩压及舒张压较术前有所下降,但在正常范围;术后收缩压及舒张压较术前有所下降,但在正常范围;术后收缩压及舒张压较术中有所升高。血氧饱和度术前组、术中组、术后组之间的差别有显著性统计学意义。术中血氧饱和度较术前有所下降,但在正常范围;术后（吸氧后）血氧饱和度较术前改善;术后（吸氧后）血氧饱和度也较术中改善。心率术前组、术中组、术后组之间的差别无统计学意义。结论：使用丙泊酚实施无痛胃镜检查安全舒适、疗效满意、不良反应少、患者依从性好,确实提高了上消化道疾病的诊疗水平。

Clinical Application of Propofol for Patients Undergoing Painless Gastroscopy

OBJECTIVE： To observe the efficacy and safety of propofol （vein anesthesia） for patients undergoing painless gastroscopy. METHODS： 1 031 patients were anesthetized with propofol continuous infusion using micro pump. The blood pressure, SPO2 and heart rate were recorded before, during and after the anesthesia （operation）, and the side effect, recovery time and comfort degree of patients were recorded as well. RESULTS： The differences of the blood pressure （the SBP and DBP） before, during and after the operation were significant. The SBP and DBP decreased during operation as compared with before operation but were in the normal range. After operation, the SBP and DBP reduced compared with before operation but which were also in the normal range. After operation, the SBP and DBP increased compared with during operation. The differences of the SPO2 before, during and after the operation were significant. SPO2 reduced during operation but it was in normal range, whieh had improvement after operation （following oxygen inhalation） compared with before and during operation. The differences of the heat rate before, during and after the operation were nonsignificant. CONCLUSION ： Propofol was proved to be safe, comfortable to use, satisfactory in efficacy yet with few side effects in patients undergoing painless gastroseopy, meanwhile, patients had good compliance to which and it can effectively enhance the diagnostic and treatment level of upper gastric diseases.