青蒿素及其衍生物在皮肤病领域的研究与应用

青蒿及其衍生物长期以来一直受到临床医师的广泛重视。新近研究发现除抗疟效果外,青蒿类药物还具有抗炎抑菌、抗组织纤维化增生以及免疫抑制/调节等多种效用,加之其为中草药,疗效好,无不良反应,在皮肤病治疗方面具有广阔的药物开发前景和应用价值。该文就青蒿素及其衍生物在皮肤科的基础研究与临床应用予以综述。

The Research and Application of Artemisinin and Its Derivatives in the Field of Dermatosis

Artemisinin and its derivatives are attracting growing concern of clinical doctors for a long time. Recent studies have found that besides the anti-malaria effect,artemisinin and its derivatives had many other pharmacologic actions such as anti-infective, antifungal, inhibiting proliferation of fibroblast cells, immune suppression/regulation. As traditional Chinese-drug, they have ideal effect with less adverse reaction, therefore broad prospect and application value in treating dermatosis are expected. Here is to make a review of the basic research and clinical application of artemisinin and its derivatives.