Heme oxygenase system in hepatic ischemia-reperfusion injury |
| |
| Authors: | Richards James A Wigmore Stephen J Devey Luke R |
| |
| Affiliation: | James A Richards, Stephen J Wigmore, Luke R Devey, Centre for Inflammation Research, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, EH16 4TJ, United Kingdom |
| |
| Abstract: | Hepatic ischemia-reperfusion injury (IRI) limits access to transplantation. Heme oxygenase-1 (HO-1) is a powerful antioxidant enzyme which degrades free heme into biliverdin, free iron and carbon monoxide. HO-1 and its metabolites have the ability to modulate a wide variety of inflammatory disorders including hepatic IRI. Mechanisms of this protective effect include reduction of oxygen free radicals, alteration of macrophage and T cell phenotype. Further work is required to understand the physiological importance of the many actions of HO-1 identified experimentally, and to harness the protective effect of HO-1 for therapeutic potential. |
| |
| Keywords: | Ischemia-reperfusion injury Heme oxygenase Transplantation Ischemic pre-conditioning |
| 本文献已被 维普 PubMed 等数据库收录！ |
|
