Development and evaluation of cefadroxil drug loaded biopolymeric films based on chitosan-furfural schiff base |
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| Authors: | Dixit Ritu B Uplana Rahul A Patel Vishnu A Dixit Bharat C Patel Tarosh S |
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| Affiliation: | 1 Ashok & Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar-388121, India;2 Department of Pharmaceutics, A. R. College of Pharmacy, Vallabh Vidyanagar-388120, India;3 Department of Chemistry, V. P. & R. P. T. P. Science College, Vallabh Vidyanagar-388120, India |
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| Abstract: | Cefadroxil drug loaded biopolymeric films of chitosan-furfural schiff base were prepared by reacting chitosan with furfural in presence of acetic acid and perchloric acid respectively for the external use. Prepared films were evaluated for their strength, swelling index, thickness, drug content, uniformity, tensile strength, percent elongation, FTIR spectral analysis and SEM. The results of in vitro diffusion studies revealed that the films exhibited enhanced drug diffusion as compared to the films prepared using untreated chitosan. The films also demonstrated good to moderate antibacterial activities against selective gram positive and gram negative bacteria. |
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| Keywords: | Cefadroxil Biopolymeric films Schiff base of chitosan-furfural In vitro drug release |
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