燃煤型氟中毒对病区儿童脂质过氧化、抗氧化能力的影响

目的探讨燃煤型氟中毒对病区儿童体内脂质过氧化、抗氧化指标的影响。方法在燃煤型氟中毒不同程度病区中分别抽取30名儿童作为研究对象。采集晨尿且抽取空腹静脉血,检测尿氟及血清中MDA含量、SOD和GSH-PX活性。结果不同病区儿童之间尿氟浓度、血清MDA含量、SOD和GSH-PX活性的差异均具有统计学意义(P<0.01)。重、中病区儿童的尿氟浓度均高于对照区(P<0.01);重、中、轻病区儿童的血清MDA含量均高于对照区(P<0.05),而血清GSH-PX活力均低于对照区(P<0.05);重、中病区儿童的血清SOD活力均低于对照区(P<0.01)。血清MDA含量与尿氟含量之间呈正相关关系(r=0.64,P<0.01),而血清SOD、GSH-PX活力与尿氟含量之间呈明显负相关(r值分别为-0.45和-0.39,P<0.01)。结论过量氟摄入可引起机体抗氧化系统紊乱,脂质过氧化作用增强。

The effects of fluorosis caused by fluoride in coal on the level of lipid peroxidation and the activities of antioxidase in children

Objective To explore the influence of fluorosis caused by fluoride in coal on the level of lipid peroxidation and the activities of antioxidase in children. Methods In Leiyang county of Hunan province, thirty children were sampled re spectively in control group and severe, medium, slight fluorosis group. On an empty stomach in the morning, Urine of ob jectives was collected and venous blood was draw. Fluoride content in urine and the content of MDA, the activities of SOD and GSH-PX in serum was measured respectively. Results The difference of children＇s urinary fluoride content and the content of MDA, the activities of SOD and GSH-PX in serum was significant among every group （P 〈 0.01）. The urinary fluoride contents in children of severe and medium fluorosis groups were significantly higher than control group（P 〈 0.01）. the contents of MDA in serum in children of slight, medium and severe fluorosis groups were higher than control group（P 〈 0. 05）, and the activities of GSH-PX in serum were lower than control group （P 〈 0.05）. the contents of SOD in serum in children of severe and medium fluorosis groups were lower than control group （P 〈 0.01）. There was significantly positive correlation between the MDA content and urinary fluoride content （r =0.64, P 〈 0.01）, and the activities of SOD and GSH-PX showed negative correlations with urinary fluoride content （r =-0.45, P 〈 0.01 ;r =-0.39, P 〈 0.01）. Conclusion Excess fluoride may decrease the anti-oxidation activity, and intensify the degree of lipid peroxidation.