2017年北京市健康成年人血清中季节性流感抗体水平分析 |
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引用本文: | 石伟先,吴双胜,孙瑛,崔淑娟,卢桂兰,彭晓旻,刘医萌,张代涛,赵佳琛,邹林,高洁,周景林,王全意,杨鹏.2017年北京市健康成年人血清中季节性流感抗体水平分析[J].疾病监测,2019,34(2):112-117. |
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作者姓名: | 石伟先 吴双胜 孙瑛 崔淑娟 卢桂兰 彭晓旻 刘医萌 张代涛 赵佳琛 邹林 高洁 周景林 王全意 杨鹏 |
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作者单位: | 北京市疾病预防控制中心,北京市预防医学研究中心,北京100013;北京市通州区疾病预防控制中心,北京,101100 |
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基金项目: | 北京市优秀人才培养资助青年拔尖个人项目(No. 2014000021223ZK36);首都卫生发展科研专项(No. 2018–2–1013) |
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摘 要: | 目的通过对北京市健康成年人季节性流行性感冒(流感)免疫水平的检测,为流感流行趋势进行预测预警和制定有效防控措施提供参考依据。方法2017年4月对北京市6个区(县)随机选取调查对象进行问卷调查,并采集血清标本进行甲型H1N1流感(H1N1)、甲型H3N2亚型(H3N2)、乙型Victoria系(BV)、乙型Yamagata系(BY)流感病毒抗体检测,比较不同组间的抗体阳性率及几何平均滴度(GMT)水平。结果共调查1 163人,其中645人携带≥1种抗体阳性,总体阳性率为55.46%;H1N1、H3N2、BV、BY阳性率分别为25.62%、44.88%、1.98%和3.53%;H3N2抗体的GMT最高(1∶24.75),BV抗体GMT最低(1∶5.67),各亚型抗体阳性率及GMT差异有统计学意义(P<0.001)。 成年男性H3N2、BV、BY抗体阳性率及H3N2抗体GMT高于女性,差异有统计学意义(P<0.05);不同地区来源人群H1N1、H3N2抗体阳性率及GMT差异有统计学意义(P<0.05);各年龄组间H1N1、H3N2、BY抗体阳性率及GMT差异有统计学意义(均P<0.001),其中≥60岁老年组H3N2、抗体阳性率及GMT最高,18 ~ 29岁青年组H1N1、BY抗体阳性率及GMT最高;过去1年内有接种史组H1N1、H3N2、BY抗体阳性率及GMT均高于无接种史组,差异有统计学意义(P<0.05)。结论北京市健康成年人中BV、BY抗体阳性率较低,导致流感暴发的风险较大;影响不同亚型流感病毒抗体水平的影响因素略有不同,疫苗接种等因素与抗体阳性存在相关性。
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关 键 词: | 健康成年人 季节性流感病毒 抗体 |
收稿时间: | 2018-06-15 |
Analysis on antibody levels to seasonal influenza viruses in healthy adults in Beijing, 2017 |
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Institution: | 1.Beijing Municipal Center for Disease Control and Prevention, Beijing Research Center for Preventive Medicine, Beijing 100013, China2.Tongzhou District Center for Disease Control and Prevention, Beijing 101100, China |
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Abstract: | ObjectiveTo investigate the immune level against seasonal influenza viruses in healthy adults in Beijing.MethodsIn April 2017, the study subjects were randomly selected from communities in six districts in Beijing. A questionnaire survey was conducted among them and serum samples were collected from them to detect the antibodies against seasonal influenza viruses, including influenza A (H1N1) pdm09 virus, influenza A (H3N2) virus, influenza B virus Victoria lineage and influenza B virus Yamagata lineage. The positive rates of the antibodies and the genmetric mean titers (GMTs) in different groups were compared.ResultsA total of 1 163 healthy adults were surveyed, in which 645 were positive for at least one antibody. The positive rates for A (H1N1) pdm09, A (H3N2), B Victoria lineage and B Yamagata lineage viruses were 25.62%, 44.88%, 1.98% and 3.53% respectively. The antibody against A (H3N2) virus had the highest GMT of 1∶24.75, while the GMT of antibody against B Victoria lineage virus was lowest (1∶5.67). The differences in antibody positive rate and GMT were significant among the four subtype influenza viruses (P<0.001). The positive rates of antibodies against A (H3N2), B Victoria lineage and B Yamagata lineage viruses and the GMT of A (H3N2) virus antibody were higher in males than in females (P<0.05). There were significant differences in positive rates of antibodies against A (H1N1) pdm09 virus and A (H3N2) virus and the GMTs among the populations from different districts (P<0.05). Similar results were observed in different age groups for the positive rates of antibodies against A (H1N1) pdm09, A (H3N2) and B Yamagata lineage viruses (P<0.001). The antibody level to A (H3N2) virus and GMT were highest in age group ≥60 years , while the antibody levels to A (H1N1) pdm09 virus and B Yamagata lineage virus and GMTs were highest in age group 18–29 years. The persons receiving vaccination in past year had higher positive rates of antibodies and GMTs against A (H1N1) pdm09, A (H3N2) and B Yamagata lineage viruses compared with unvaccinated persons (P<0.05).ConclusionThe positive rates of antibodies against B Victoria lineage and B Yamagata lineage viruses were low in healthy adults in Beijing, suggesting the high risks for outbreaks of infections of B Victoria lineage and B Yamagata lineage viruses. The factors influencing the antibody levels of different subtype influenza viruses slightly differed, and there was a correlation between vaccination or other factors and antibody positive rate. |
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