冠心病患者血尿酸及同型半胱氨酸水平与冠脉病变严重程度的关系

目的:观察分析冠心病患者血清尿酸（UA）及同型半胱氨酸水平（homocysteine，Hcy）与冠状动脉病变程度的关系及其临床意义。方法:回顾性分析我院经冠状动脉造影诊断冠心病患者165例，按Gensini评分分为3组，A组（<20分组）、B组（20~40分组）、C组（>40分组），另将冠状动脉造影正常的54例患者作为正常对照组。分别比较各组间UA、Hcy水平。结果:冠心病患者的UA、Hcy的水平显著高于正常对照组（P<0.05），且不同Gensini积分组C组与A和B组UA、Hcy水平之间差异也有统计学意义（P<0.05）。结论:UA、Hcy水平与冠脉病变严重程度密切相关。

Relationship between blood uric acid and homocysteine and severity of coronary artery lesion

AIM:To investigate the relations between the levels of blood uric acid (UA) and serum homocysteine (HCY) and the severity of coronary artery lesions in patients with coronary heart disease (CHD). METHODS: Patients were divided into CHD group (165 cases) and normal control group (54 cases) depending on the results of the coronary angiography. According to Gensini scores, we subdivided the CHD group into three groups: Group A (<20 points), Group B (20-40 points) and Group C (>40 points). The concentrations of blood uric UA and serum HCY were compared among groups. RESULTS: The levels of blood UA and serum homocysteine HCY in CHD groups were obviously higher than those in normal control group (P<0.05), with statistically significant difference between groups with different Gensini scores (P<0.05). CONCLUSION: Concentrations of blood UA and serum HCY are closely related to the severity of coronary artery lesions and can be a severity predictor of coronary artery lesions.