| 儿童心力衰竭发病机制研究进展 |
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| 引用本文： | 穆珺,杨世伟,秦玉明. 儿童心力衰竭发病机制研究进展[J]. 心脏杂志, 2019, 31(6): 727-730. DOI: 10.12125/j.chj.201904032 |
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| 作者姓名： | 穆珺 杨世伟 秦玉明 |
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| 作者单位： | 南京医科大学附属儿童医院心内科，江苏 南京 210019 |
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| 基金项目： | 国家自然科学基金项目资助（81670284）；南京市科技局项目资助（201715057）；南京市医学科技发展资金青年人才工程项目资助（QRX17024） |
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| 摘 要： | 心力衰竭(heart failure, HF)是多种原因及疾病进展导致的复杂临床综合征。儿童HF的病因与成人显著不同，其主要原因是先天性心脏病和原发性心肌病。本文将从血流动力学改变、遗传与表观遗传因素、分子结构及神经激素等其他机制多方面对近年来儿童HF发病机制研究进展进行综述。
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| 关 键 词： | 心力衰竭 先天性心脏病 原发性心肌病 |
| 收稿时间： | 2019-04-15 |
Research progress in pathogenesis of heart failure in children with congenital heart disease. |
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| Affiliation: | Department of Cardiology, Children’s Hospital, Nanjing Medical University, Nanjing 210019, Jiangsu, China |
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| Abstract: | Heart failure is a complex clinical syndrome caused by various causes and disease progression. The causes of heart failure in pediatric patients are significantly different from those in adult patients. Congenital heart disease and primary cardiomyopathy are the main causes in pediatric heart failure patients. This article will review the research progress in the pathogenesis of heart failure in pediatric patients in recent years from the aspects of hemodynamic changes, genetic and epigenetic factors, and other mechanisms including molecular structure and neurohormones. |
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