血浆血栓调节蛋白与冠状动脉慢血流的相关性

目的 探讨血浆血栓调节蛋白（thrombomodulin，TM）与冠状动脉慢血流（coronary slow flow，CSF）的相关性。 方法 回顾性分析184例疑似心绞痛症状，但经冠状动脉造影检查确诊无明显冠状动脉狭窄病变患者，按有无CSF分为CSF组和正常血流组。收集收缩压、舒张压、血糖和血脂等临床资料，记录CSF的重要指标校正的TIMI帧数（CTFC），检测血浆中TM的水平，进行相关分析。 结果 单因素分析发现两组收缩压、TM及CTFC有统计学差异（均P<0.01）；经非条件多因素Logistic回归分析得TM是CSF发生的独立相关因素（P<0.05）；经Spearman相关分析可得TM与CTFC呈正相关（r=0.86，P<0.05）。 结论 TM与CTFC呈正相关，是CSF的独立相关因素。

Correlation between plasma thrombomodulin and coronary slow flow

AIM To investigate the correlation between plasma thrombomodulin (TM) and coronary slow flow (CSF). METHODS Retrospective analysis was performed in 184 suspected angina pectoris patients without obvious coronary artery stenosis by coronary angiography. The patients were divided into a CSF group or normal flow group according to CSF occurrence or not. Clinical data including SBP, DBP, blood glucose, and lipids were collected. Corrected TIMI frame count (CTFC), which indicates occurrence of CSF was recorded. Levels of plasma TM were determined. The results were analyzed to determine if there is correlation between CSF and other indicators. RESULTS Single factor analysis revealed that there were significant difference between SBP, plasma TM, and CTFC in the two groups (all P<0.01). Unconditional multivariate logistic regression analysis showed that plasma TM was an independent relative factor for CSF (P<0.05). Spearman rank correlations analysis showed that there was a positive correlation between plasma TM and CTFC (r=0.86, P<0.05). CONCLUSION There is a positive correlation between plasma TM and CTFC, and plasma TM is an independent relative factor for CSF.