| 黄芪注射液及提取成分对小鼠肝脂质过氧化物的影响 |
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| 引用本文： | 张静华,龚志铭,郑基蒙,刘星堦,沈保华,陈黎明. 黄芪注射液及提取成分对小鼠肝脂质过氧化物的影响[J]. 复旦学报(医学版), 1992, 0(5) |
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| 作者姓名： | 张静华 龚志铭 郑基蒙 刘星堦 沈保华 陈黎明 |
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| 作者单位： | 上海医科大学华山医院药剂科(张静华，龚志铭，郑基蒙)，药学院天然药物化学教研室(刘星堦，沈保华)，药学院天然药物化学教研室(陈黎明) |
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| 摘 要： | 采用在体和离体两种方法研究黄芪注射液及提取成分木糖-葡萄糖-环黄芪醇(XGA)对小鼠肝匀浆脂质过氧化物(LPO)水平的影响。实验结果表明:黄芪注射液及XGA能够明显抑制小鼠离体肝脏的脂质过氧化物的生成作用,抑制率分别为27.4％和31.5％(P<0.05);并且能够抑制阿霉素引起的小鼠体内脂质过氧化物水平的升高,抑制率分别为41.2％和83.8％(P<0.05和0.01)。
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| 关 键 词： | 脂质过氧化物 黄芪注射液 木糖-葡萄糖-环黄芪醇 阿霉素 |
EFFECT OF ASTRAGALUS MEMBRANACDUS INJECTIONAND ITS COMPONENT XGA ON LIPID PEROXIDESLEVEL IN MICE LIVER |
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| Zhang Jinghua,Gong Zhiming,Zheng Jimong,Liu xingjie,Shen Baohua,Oheng Liming. EFFECT OF ASTRAGALUS MEMBRANACDUS INJECTIONAND ITS COMPONENT XGA ON LIPID PEROXIDESLEVEL IN MICE LIVER[J]. Fudan University Journal of Medical Sciences, 1992, 0(5) |
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| Authors: | Zhang Jinghua Gong Zhiming Zheng Jimong Liu xingjie Shen Baohua Oheng Liming |
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| Abstract: | The effects of Astragalus membranaceuS injection (AMI) and its extracted component Xylose-Glucose-Oycloastragenol (XGA) on the level of lipid peroxides (LPO) in mice liver were studied both in vitro and in woo. The results indicate that AMI and XGA markedly inhibit the production of LPO of mice liver in vitro, with a inhibiting rate of 27.7% and 31.5%, respectively, (P<0.05); AMI and XGA also restrain the LPO increase caused by Adriamycin in mice, with a inhibiting of 41.2% and 83.8%, respectively (P<0.05 and 0.001). |
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| Keywords: | lipid peroxides astragalus tnembranaoeus injection xylose-glucose cycloastragenol (XGA) adriamycia |
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