鸦胆子油乳剂对家兔颅内压的影响

本研究应用侧脑室插管连续描记颅内压方法，观察了中药鸦胆子油静脉乳剂及口服乳剂对家兔颅内压的影响。结果表明：鸦胆子油静脉乳剂具有较强的对抗硝普钠引起的颅内压升高作用（Ｐ＜０．０１），口服乳剂也有轻度拮抗颅内压升高作用；两种剂型对家兔正常颅内压及血压影响不大。这与鸦胆子乳剂可使肺癌脑转移引起的颅内压升高症状缓解的临床观察结果是一致的。

Experimental Study on Effect of Brucea Javanica Oil Emulsion on Rabbit Intracranial Pressure

Using the method of intubation into lateral cerebral ventricle, the effect of Burcea javanica oil emulsion(BJOE) venous emulsion and oral emulsion on rabbits with normal and intracranial hypertension respectively were observed, to study whether BJOE could reduce intracranial pressure or not. The results shown that venous emulsion of BJOE had strong action against the elevation of intracranial pressure produced by SNP p(P<0.01) while oral emulsion had mild action against it,which was similar to the clinical observation exhibiting improvement of clinical manifestions after application of BJOE on intracranial hypertension caused by brain metastasis from lung cancer.