| 一氧化氮抑制白介素-1诱导血管内皮细胞粘附分子-1的表达 |
| |
| 引用本文： | 霍玉庆,徐成斌,王申五,张杰,张彤,崔俊峰,尹春琳.一氧化氮抑制白介素-1诱导血管内皮细胞粘附分子-1的表达[J].基础医学与临床,1999,19(4):38-41. |
| |
| 作者姓名： | 霍玉庆 徐成斌 王申五 张杰 张彤 崔俊峰 尹春琳 |
| |
| 作者单位： | 1. 北京医科大学人民医院心血管内科,中心实验室,北京,100044
2. 山东泰安中医院 |
| |
| 摘 要： | 以硝普钠作为一氧化氮的供体。用流式细胞仪荧光强度测定、细胞ELISA、Northern杂交等方法分别从蛋白表达、基因表达水平研究一氧化氮对内皮细胞粘附分子VCAM-1表达的影响。结果表示：一氧化氮抑制IL－1α诱发的内皮细胞粘附分子VCAM－1的基因表达水平其作用里浓度及时间依赖性。一氧化氮抑制内皮细胞粘附分子VCAM－1的表达是其抑制单核一内皮细胞粘附及抗动脉粥样硬化的机制之一．
|
| 关 键 词： | 一氧化氮 内皮细胞 血管细胞粘附分子 |
Nitric Oxide Inhibits VCAM-1 Expression of Human Endothelial Cell Activated by IL-1 |
| |
| Huo Yuqing, Xu Chengbin,Wang Shenwu et al.Nitric Oxide Inhibits VCAM-1 Expression of Human Endothelial Cell Activated by IL-1[J].Basic Medical Sciences and Clinics,1999,19(4):38-41. |
| |
| Authors: | Huo Yuqing Xu Chengbin Wang Shenwu |
| |
| Abstract: | FCAS, cell ELISA and Nortnern blot were applied to study the effects of nitroprosside, a donorof nitric oxide on the expression of protein and mRNA of VCAM-1. Results showed that nitroprussideinhibit6d Expression of VCAM-1 protein and mRNA in a dose-and time-dependent manner. It impliesthat, inhibitory effect of nitric oxide on VCAM-1 expression could be one of the mechanismsunderlying antiadhesion between monocyte and vascular endothelial cells, and antiatherosclerosis. Correspondence to professor Xu Chengbin |
| |
| Keywords: | Nitric oxide Vascular adhesion molecule Endothelial cell |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
