| 血小板衍生生长因子对成纤维细胞合成胶原的影响 |
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| 引用本文： | 董茂龙,陈璧,徐明达.血小板衍生生长因子对成纤维细胞合成胶原的影响[J].中华整形外科杂志,2000,16(2):78-80. |
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| 作者姓名： | 董茂龙 陈璧 徐明达 |
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| 作者单位： | 第四军医大学西京医院烧伤外科 |
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| 摘 要： | 目的 探讨血小板衍生生长因子（ＰＤＧＦ－ＡＢ）促进伤口愈合的作用机理及其在瘢痕增生中的作用。方法 取体外培养的人正常皮肤及增生性瘢痕成纤维细胞，用原位杂交法观察ＰＤＧＦ对两种细胞表达Ｐｒｏα１（Ⅲ）ｍＲＮＡ的影响。结果；ＰＤＧＦ－ＡＢ对两种成纤维细胞表达Ｐｒｏ α１（Ⅲ）ｍＲＮＡ均有明显促进作用，且均呈剂量依赖性关系，但作用有差异。
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| 关 键 词： | PDGF－AB 成纤维细胞 原位杂交 瘢痕 |
| 修稿时间： | 1998-09-02 |
The effects of PDGF-AB on pro alpha 1 (III). mRNA expression of fibroblasts] |
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| M Dong,B Chen,M Xu.The effects of PDGF-AB on pro alpha 1 (III). mRNA expression of fibroblasts][J].Chinese Journal of Plastic Surgery,2000,16(2):78-80. |
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| Authors: | M Dong B Chen M Xu |
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| Institution: | Department of Burn Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China. |
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| Abstract: | OBJECTIVE: To investigate the mechanism of PDGF-AB to promote wound healing and its role during the process of scar formation. METHODS: In vitro cultured fibroblasts of human normal skin and hypertrophic scar were treated with PDGF-AB. The expression of Pro alpha 1 (III) mRNA of the fibroblasts was evaluated by in situ hybridization technique. RESULTS: PDGF-AB could increase Pro alpha 1 (III) mRNA expression of fibroblasts of both normal skin and hypertrophic scar in a dose-dependent manner. However, the effect of PDGF-AB on hypertrophic scar fibroblasts was stronger. CONCLUSIONS: PDGF-AB may promote wound healing by stimulating extracellular matrix synthesis, e.g. collagen. PDGF-AB may also play a role in scar formation through collagen deposition. |
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| Keywords: | PDGF AB Fibroblast In situ hybridization Scar |
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