血清胱抑素C在老年原发性高血压患者肾功能损害诊断中的应用价值

目的探讨血清胱抑素C(Cys C)在老年原发性高血压(EH)患者肾功能损害诊断中的应用价值。方法将90例老年原发性高血压患者按尿白蛋白排泄率(UAER)分为正常蛋白尿组30例(UAER<20μg/min),微量蛋白尿组(UAER20~199μg/min)30例和大量蛋白尿组(UAER≥200μg/min)30例。测定各组Cys-C、血清肌酐(Scr)、肾小球滤过率(GFR)和UAER。结果随着UAER的增加,Cys-C、Scr和BUN明显增加,GFR逐渐下降;Cys-c与BUN、Scr和UAER呈正相关,与GFR呈负相关,但以Cys-C与GFR相关性最强(r=-0.72,P<0.05)。结论 Cys-C与老年原发性高血压患者肾功能损伤有明显的相关性,在老年原发性高血压肾功能损害,尤其是在早期肾功能损害的诊断中具有很好的诊断价值。

Diagnosis Value of Serum Cystatin C for Renal Impairment in Elderly Patients with Hypertension

Objective To evaluate the value of serum cystatin C for the diagnosis of renal impairment in elderly hypertension patients. Methods 90 elderly essential hypertensive patients, which were divided into three groups by urinary albumin excretion rate （UAER）. The data of serum Cystain C, serum creatinine （Scr）, blood ureanitrogen （BUN） and GFR were obtained and analyzed. Results The level of Cys C, GFR showed significant differences of three groups （P〈0.05）. The level of Scr, BUN in microalbuminuria group was higher than that in large proteinuria group （P〈0.05）. Univariate analysis implied that Cys C was positively related with Scr and BUN （P〈0.05）. Cys C was negatively correlated with GFR （P 〈0.05）. Conclusion Cyst C should be a sensitive indicator for renal impairment of elderly hypertension patients, especially for early renal impairment.