Girdin和BCL-2蛋白在脑胶质瘤组织中表达及其意义

【目的】探讨肌动蛋白丝束小梁(Girdin)和B淋巴细胞瘤-2(BCL-2)蛋白在脑股质瘤组织中表达及其意义。【方法】选取2010年3月至2013年1月在本院诊治并经病理学确诊的脑胶质瘤患者53例,采用免疫组织化学染色法检测53例患者脑肢质瘤组织及瘤旁正常组织中Girdin和BCL-2蛋白的表达水平,分析其表达水平与患者各临床病理特征、术后总生存期的关系。【结果】脑胶质瘤中G ird in蛋白、BCL-2蛋白阳性表达率为60.38%(32/53)、41.51%(22/53),均显著高于正常组织的5.66%(3/53)、1.89%(1/53),其差异均具有统计学意义(P<0.05)。脑胶质瘤组织中Girdm蛋白表达水平与患者病理学分级、瘤周水肿及肿瘤肉眼直径有关(P<0.05);脑胶质瘤组织中BCL-2蛋白表达水平与患者性别有关(P<0.05)。Girdin蛋白高表达患者生存率明显低于低表达患者,其差异具有统计学意义(P<0.05);BCL-2蛋白高表达和低表达的患者生存率比较差异无统计学意义(P>0.05)。【结论】Girdin和BCL-2蛋白在脑胶质瘤组织中呈高表达;Girdin蛋白参与脑股质瘤的发展,并对其预后有负面影响。

Expression and Significance of Girdin and BCL-2 Protein in Glioma Tissue

【Objeetive】To investigate the expression and significance of Girdin and B-Iycytoma-2(BCL-2)proteins in glioma tissues.【Methods】From March 2010 to January 2013,53 patients with gliomas diagnosed and treated in our hospital were selected.The expression of Girdin and BCL-2 protein in gliomas and normal tissues adjacent to gliomas were detected by immunohistochenmiry.The relationship between the expression level and the clinicopathological characteristics of patients and the total survival period was analyzed.【Results】The positive rates of Girdin and BCL-2 protein in gliomas were 60.38%(32/53)and 11.51%(22/53).which were significantly higher than those in normal tissues 5.66%(353)and 1.89%(153).The differ ences were statistically significant(P<0.05).The expression level of Girdin protein in gliomas was related to pathological grade,peritumoral edema and gross diameter of tumor(P<0.05);the expression level of Bcl-2 protein in gliomas was related to gender(P<0.05).The survival rate of patients with high expression of Gir din protein was significantly lower than that of patients with low expression(P<0.05).and there was no significant difference between patients with high expression of BCL-2 protein and patients with low expression of BCL-2 protein(P>0.05).【Conclusion】Girdin and BCL-2 protein are highly expressed in gliomas.Girdin protein is involved in the development of gliomas and has a negative impact on their prognosis.