依达拉奉联合开颅血肿清除术对中等量基底核区高血压脑出血患者神经功能的影响

目的探讨依达拉奉联合开颅血肿清除术对中等量基底核区高血压脑出血患者神经功能的影响。方法选取医院2017年8月至2019年8月收治的中等量基底核区高血压脑出血患者86例,按随机抽样方法分为观察组和对照组,各43例。两组患者均行开颅血肿清除术,观察组患者加用依达拉奉。两组患者均持续治疗2周。结果观察组总有效率为93.02%,显著高于对照组的76.74%(P<0.05);与对照组比较,治疗后,观察组美国国立卫生研究院卒中量表(NIHSS)评分显著降低,格拉斯哥昏迷量表评分(GCS)和蒙特利尔认知评估量表(MoCA)评分均显著提高(P<0.05),神经元特异性烯醇化酶(NSE)、超敏C反应蛋白(hs-CRP)和S-100β蛋白水平均显著降低(P<0.05),生活质量各项评分均显著提高(P<0.05);观察组与对照组不良反应发生率相当(13.95%比9.30%,P>0.05)。结论依达拉奉联合开颅血肿清除术治疗中等量基底核区高血压脑出血疗效良好,能改善患者的神经功能,提高生活质量,且安全性良好。

Effect of Edaravone Combined with Craniotomy for the Evacuation of Hematoma on Neurologic Function in Patients with Moderate Hypertensive Basal Ganglia Hemorrhage

Objective To investigate the effect of edaravone combined with craniotomy for the evacuation of hematoma on neurologic function in patients with moderate hypertensive basal ganglia hemorrhage(HBGH).Methods Totally 86 patients with moderate HBGH admitted to our hospital from August 2017 to August 2019 were selected and divided into the observation group and the control group according to the way of random sampling,43 cases in each group.The patients in the two groups underwent craniotomy for the evacuation of hematoma,on this basis,the patients in the observation group were treated with edaravone.Both groups were continuously treated for 2 weeks.Results The total effective rate of the observation group was 93.02%,which was significantly higher than 76.74%of the control group(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score in the observation group was significantly lower than that in the control group,the Glasgow Coma Scale(GCS)score and Montreal Cognitive Assessment(MoCA)score in the observation group were significantly higher than those in the control group(P<0.05).The levels of neuron-specific enolase(NSE),high sensitivity C-reactive protein(hs-CRP)and S-100βprotein in the observation group were significantly lower than those in the control group(P<0.05).The scores of quality of life in the observation group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(13.95%vs.9.30%,P>0.05).Conclusion Edaravone combined with craniotomy for the evacuation of hematoma is effective and safe in the treatment of patients with moderate HBGH,it can improve neurological function and the quality of life.