癌症疼痛患者阿片类药物剂量计算的临床推荐

阿片类药物是肿瘤患者中重度疼痛的主要治疗药物,但由于该类药物存在较大的个体差异性和用药风险,正确进行阿片类药物剂量滴定和换算在有效减轻患者疼痛的同时还可避免过度治疗造成的不良反应。目前临床上常用的阿片类药物剂量计算有阿片初始剂量的滴定,爆发痛剂量计算,不同阿片药物以及不同剂型的换算,肝、肾功能不全患者阿片类药物的给药剂量等。该文结合国内外研究报道,对上述几种剂量计算进行了综述,为临床合理用药提供参考。

Clinical Recommended Dose for Opioids in the Treatment of Cancer Pain Patient

Opioids are common medications used to treat moderate and severe pain in cancer patients.However,as their significant individual variation in efficacy and medication risk among patients,the dosage of opioids often needs to be accurately titrated or conversed mutually to alleviate pain and avoid adverse reactions caused by overtreatment.Currently,the common calculation used in opioid dosage includes opioid titration,opioid dosage calculation of outbreak pain,opioid rotation between different drugs or formulations,dosage adjustment associated with liver and renal insufficiency,et al.In order to provide reference for clinical rational drug use,we reviewed those dose calculations of opioids based on domestic and foreign reports.