吉西他滨的药效学与药动学及其节拍化疗研究进展

目的综述吉西他滨的药效动力学(简称药效学)与药物代谢动力学(简称药动学)及其在节拍化疗中的研究进展,为临床制定安全有效的给药方案提供借鉴。方法以"gemcitabine""pharmacodynamics""pharmacokinetics""metronomic chemotherapy"为关键词,查询PubMed及Web of Science等数据库中收录的相关文献,并从药效学作用、药动学过程、节拍化疗中的研究进展3个方面进行综述。结果与结论吉西他滨属胞嘧啶核苷类抗肿瘤药物,用于多种实体肿瘤尤其是胰腺癌与肺癌的治疗。吉西他滨是最早应用于节拍化疗的抗肿瘤药物之一,单用或与顺铂、紫杉醇等多种细胞毒类药物联用化疗效果良好,临床疗效显著。

Pharmacodynamics and Pharmacokinetics of Gemcitabine and Its Research Progress in Metronomic Chemotherapy

Objective To review the pharmacodynamics and pharmacokinetics of gemcitabine and its research progress in metronomic chemotherapy,and to provide a reference for the formulation of its safe and effective clinical dosing regimen.Methods The″gemcitabine″″pharmacodynamics″″pharmacokinetics″and″metronomic chemotherapy″were taken as keywords to search the relevant documents included in the PubMed and Web of Science databases for reviewing the pharmacodynamic effect,pharmacokinetic process and the research progress of metronomic chemotherapy.Results and Conclusion Gemcitabine is a kind of cytosine nucleoside antitumor drug,which is used in the treatment of a variety of solid tumors,especially pancreatic cancer and lung cancer.Gemcitabine is one of the earliest antineoplastic agents used in metronomic chemotherapy,and gemcitabine alone or in combination with various cytotoxic drugs such as cisplatin and paclitaxel has shown good chemotherapy effects and clinical efficacy.