| 免疫检查点抑制剂对耐药结直肠癌的研究现状 |
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| 引用本文： | 袁沁,吴宏磊,徐可,殷佩浩.免疫检查点抑制剂对耐药结直肠癌的研究现状[J].中国临床药理学杂志,2021(2):183-185. |
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| 作者姓名： | 袁沁 吴宏磊 徐可 殷佩浩 |
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| 作者单位： | 成都中医药大学医学与生命科学学院;上海市普陀区中心医院普外科;上海中医药大学中西医结合肿瘤介入研究所 |
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| 基金项目： | 国家自然科学基金面上基金资助项目(81873137);上海市进一步加快中医药事业发展三年行动计划(2018年-2020年)人才类基金资助项目(ZY(2018-2020)-RCPY-2016)。 |
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| 摘 要： | 错配修复缺陷(dMMR)/微卫星高频不稳定(MSI-H)结直肠癌因其致癌机制引起程序性细胞死亡蛋白1(PD-1)/程序性细胞死亡配体1(PD-L1)上调,对5-氟尿嘧啶(5-FU)等为基础的化疗方案产生肿瘤免疫性抵抗,出现耐药性。本文从以下几方面进行综述:dMMR/MSI-H结直肠癌耐药的特点和PD-1/PD-L1抑制剂在肿瘤中的生物学功能以及关于PD-1/PD-L1抑制剂单一治疗、联合其他治疗等治疗方法在耐药dMMR/MSI-H CRC治疗中的研究进展,为以后相关的临床研究提供新的想法。
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| 关 键 词： | 错配修复缺陷/微卫星不稳定性高结直肠癌 程序性细胞死亡1/程序性细胞死亡配体1 抑制剂 耐药 |
Current status of immune checkpoint inhibitors in drug-resistant colorectal cancer |
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| YUAN Qin,WU Hong-lei,XU Ke,YIN Pei-hao.Current status of immune checkpoint inhibitors in drug-resistant colorectal cancer[J].The Chinese Journal of Clinical Pharmacology,2021(2):183-185. |
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| Authors: | YUAN Qin WU Hong-lei XU Ke YIN Pei-hao |
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| Institution: | (School of Medicine and Life Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan Province,China;Department of General Surgery,Putuo District Central Hospital of Shanghai y Shanghai 200062,China;Interventional Cancer Institute of Chiriese Integrative Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China) |
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| Abstract: | Mismatch repair defects(dMMR)/microsatellite high-frequency instability(MSI-H)in colorectal cancer cause upregulation of programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1)due to its carcinogenic mechanism,resulting in tumor-immune resistance and drug resistance to 5-fluorouracil(5-Fu)and other chemotherapy regimens.This paper summarized the following aspects:the characteristics of drug resistance of dMMR/MSI-H colorectal cancer,the biological function of PD-1/PD-L1 inhibitors in tumors,and the research progress of single therapy of PD-1/PD-L1 inhibitors and other treatment methods in the treatment of drug-resistant dMMR/MSI-H CRC,so as to provide new ideas for related clinical studies in the future. |
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| Keywords: | mismatch repair deficient/microsatellite instability-high colorectal cancer programmed cell death 1/programmed cell death ligand 1 inhibitor drug resistance |
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