卵巢上皮癌中血管生成拟态和E-钙黏蛋白表达及其临床意义

目的: 探讨血管生成拟态 (vasculogenic mimicry, VM)与E-钙黏蛋白(E-cadherin, E-cad)在人卵巢上皮癌(epithelial ovarian cancer,EOC) 组织中的表达及意义。方法: 收集80例EOC标本和20例卵巢良性上皮性肿瘤标本,应用免疫组化法和组织化学法检测EOC和卵巢良性上皮性肿瘤组织中VM和E-cad的表达情况。结果: 在EOC和卵巢良性上皮性肿瘤组织中,VM和E-cad的阳性表达率分别为57.4%、0%和48.7%、75.0%,差异均显著(P＜0.05或P<0.01);VM及E-cad的表达与EOC的组织学分级、腹腔脏器及淋巴结转移以及临床PTNM分期有关(P＜0.05);VM与E-cad在EOC中的表达呈负相关(r=-0.578,P＜0.01)。多因素分析:PTNM分期、腹腔脏器及淋巴结转移、VM和E-cad的表达是影响EOC根治术后患者预后的独立因素(P＜0.05);VM阳性组与阴性组的5年生存率分别为4.3%和88.2%,E-cad阳性组与阴性组的5年生存率分别为71.8%和9.8%,差异均显著(P＜0.05)。结论: 具有VM的EOC组织分化低,患者临床预后差;VM与E-cad的表达水平与EOC的发展及预后有一定的关系。

Vasculogenic mimicry and E-cadherin expression in epithelial ovarian cancer

AIM: To explore whether vasculogenic mimicry(VM) exists in human epithelial ovarian cancer(EOC),and to elucidate the relationship between E-cadherin(E-cad) expression and VM.METHODS: The E-cad expression and VM in 80 specimens of EOC and 20 specimens of benign ovarian epithelial tumor tissues were detected by the methods of immunohistochemical and histochemical staining.RESULTS: The positive rates of VM and E-cad protein in EOC were 57.4% and 48.7%,respectively.The positive rates of VM and E-cad protein in ...