| Stathmin在上皮性卵巢癌组织中的表达及意义 |
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| 引用本文： | 石英,翁艳洁,周文娟,周婷,陈刚,王常玉.Stathmin在上皮性卵巢癌组织中的表达及意义[J].中国癌症杂志,2011,21(8). |
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| 作者姓名： | 石英 翁艳洁 周文娟 周婷 陈刚 王常玉 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院妇产科,湖北,武汉,430030 |
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| 摘 要： | 背景与目的:Stathmin是一种重要的微管调节蛋白,参与多种肿瘤的发生、发展.本研究旨在验证并探讨Stathmin在上皮性卵巢癌中的表达及意义.方法:利用免疫组化和逆转录聚合酶链反应(RT-PCR)方法检测22例卵巢正常上皮组织,16例良性肿瘤和50例上皮性卵巢癌组织中Stathmin的表达.结果:上皮性卵巢癌中Stathmin mRNA的表达明显高于卵巢良性肿瘤(P<0.05)和正常卵巢上皮(PO.05).进一步利用x2检验统计分析得出,Stathmin蛋白与卵巢癌的临床分期、病理分级、淋巴转移相关(P<0.05),而与年龄、病理类型及腹水量无相关性(P>0.05).结论:Stathmin在上皮性卵巢癌中高表达,可能与卵巢癌的发生、发展相关.
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| 关 键 词： | 卵巢癌 Stathmin 免疫组化 逆转录聚合酶链反应 |
The expression and significance of Stathmin in epithelial ovarian cancer |
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| SHI Ying,WENG Yan-jie,ZHOU Wen-juan,ZHOU Ting,CHEN Gang,WANG Chang-yu.The expression and significance of Stathmin in epithelial ovarian cancer[J].China Oncology,2011,21(8). |
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| Authors: | SHI Ying WENG Yan-jie ZHOU Wen-juan ZHOU Ting CHEN Gang WANG Chang-yu |
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| Institution: | SHI Ying,WENG Yan-jie,ZHOU Wen-juan,ZHOU Ting,CHEN Gang,WANG Chang-yu(Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei 430030,China) |
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| Abstract: | Background and purpose:Stathmin is identi?ed as a kind of important microtubules regulatory protein and participates in multiple tumorigenesis.In this study,we investigated the expression and significance of Stathmin in epithelial ovarian cancer.Methods:The expression levels of Stathmin in 22 cases of normal ovarian tissues,16 cases of benign ovarian tumors and 50 cases of epithelial ovarian cancers were examined by RT-PCR and immunohistochemical staining.Results:The Stathmin mRNA expression in ovarian epit... |
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| Keywords: | Ovarian cancer Stathmin Immunohistochemistry RT-PCR |
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