GEMOX方案与GDP方案治疗复发或难治性非霍奇金淋巴瘤的临床对比研究

背景与目的:复发或难治性非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)挽救治疗疗效欠佳,至今尚无标准的挽救治疗方案,需要寻找有效且不良反应小的新方案.本研究旨在对比观察国产吉西他滨联合奥沙利铂(GEMOX方案)与吉西他滨联合顺铂、地塞米松方案(GDP方案)在复发或难治性NHL治疗中的近期疗效和不良反应.方法:58例复发或难治性NHL患者,分层随机分组,分别接受GEMOX方案和GDP方案治疗.GEMOX组:采用国产吉西他滨1 000 mg/m2,第1、8天,静脉滴注;奥沙利铂130 mg/m2,第1天,静脉滴注:3周为1个化疗周期.GDP组:国产吉西他滨1000 Mg/M2,第1,8天,静脉滴注;顺铂25 mg/m2,第1～3天,静脉滴注:地塞米松20 mg/d,第1～5天,静脉滴注:3～4周为1个化疗周期.每2个周期进行疗效及不良反应评价.结果:56例患者可评价疗效,GEMOX组:28例,CR 8例(28.6%),PR 11例(39.3%),总有效率(CR+PR)为67.9%;13例具有B类症状的患者中9例症状消失,4例明显改善:中位疾病进展时间为7.7个月.GDP组:28例,CR 5例(17.9%) ; PR 12例(42.9%),总有效率(CR+PR)为60.8%; 8例B症状患者,4例症状消失,3例症状明显改善;中位疾病进展时间为7.0个月.两组无疾病进展生存差异无统计学意义(P=O.46).化疗主要不良反应均为骨髓抑制,GEMOX方案胃肠道反应明显少于GDP组(P

Comparison of the effect of GEMOX and GDP regimen in treatment of relapsed or refractory non-Hodgkin's lymphoma

Background and purpose:The treatment result of relapsed or refractory non-Hodgkin's lymphoma is very poor as the current standard of salvage therapy.To date,an effective salvage chemotherapy regimen for the treatment of these patients has not been discovered.New active regimens with an acceptable toxicity profile are needed.This study was conducted to compare the effect and toxicity of GEMOX and GDP regimen for relapsed or refractory non-Hodgkin's lymphoma.Methods:Fifty-eight patients with histologically co...