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| 内皮素-1及一氧化氮水平与2型糖尿病听力损害的关系 | |
| 引用本文： | 陈雄,林碧,龚小花,吴文俊,陈咨苗,谷雪梅,沈飞霞. 内皮素-1及一氧化氮水平与2型糖尿病听力损害的关系[J]. 中国病理生理杂志, 2011, 27(11): 2152-2155. DOI: 10.3969/j.issn.1000-4718.2011.11.021 |
| 作者姓名： | 陈雄 林碧 龚小花 吴文俊 陈咨苗 谷雪梅 沈飞霞 |
| 作者单位： | 1. 温州医学院附属第一医院内分泌科,浙江 温州 325000; 2. 温州医学院附属第一医院耳鼻咽喉科,浙江 温州 325000 |
| 基金项目： | 国家自然青年科学基金资助项目，温州市科技局课题基金资助项目 |
| 摘 要： | 目的: 探讨内皮素-1(ET-1)和一氧化氮(NO)与糖尿病听力损害的关系。方法: 共入选88例2型糖尿病患者,所有患者通过相关临床并发症检查排除糖尿病伴视网膜、肾脏及神经病变,并取同期53例正常人群作为对照。对每位患者进行纯音测听判断是否存在听力损害。分别以放射免疫法及硝酸还原酶法检测所有对象血浆ET-1和血清NO水平。结果: 糖尿病伴听力损害患者血浆ET-1显著增高(P<0.01),血清NO水平显著下降(P<0.05)。多因素logistic回归分析发现高糖化血红蛋白(HbA1c)(OR:4.525,P<0.05)、高低密度脂蛋白胆固醇(LDL-C) (OR:2.381,P<0.05)、高血浆ET-1(OR:6.207,P<0.01)和低血清NO(OR:0.862,P<0.05)是糖尿病听力损害的独立危险因素。结论: 糖尿病相关听力损害发生可能早于其它并发症,高血糖、高血脂、高血浆ET-1及低血清NO水平与糖尿病听力损害的发生密切相关。 |
| 关 键 词： | 糖尿病 2型 听力损害 一氧化氮 内皮缩血管肽 1 |
| 收稿时间： | 2011-05-06 |
Relationship between levels of plasma endothelin-1/serum nitric oxide and hearing impairment in type 2 diabetes |
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| CHEN Xiong,LIN Bi,GONG Xiao-hua,WU Wen-jun,CHEN Zi-miao,GU Xue-mei,SHEN Fei-xia. Relationship between levels of plasma endothelin-1/serum nitric oxide and hearing impairment in type 2 diabetes[J]. Chinese Journal of Pathophysiology, 2011, 27(11): 2152-2155. DOI: 10.3969/j.issn.1000-4718.2011.11.021 | |
| Authors: | CHEN Xiong LIN Bi GONG Xiao-hua WU Wen-jun CHEN Zi-miao GU Xue-mei SHEN Fei-xia |
| Affiliation: | 1. Department of Endocrinology,The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China; 2. Department of Otolarynglogy,The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China |
| Abstract: | AIM: To evaluate the relationship between endothelin-1(ET-1)/nitric oxide(NO) and hearing impairment in type 2 diabetes mellitus(DM).METHODS: Eighty-eight type 2 diabetic patients with no signs of microangiopathy(retinopathy and nephropathy) or peripheral neuropathy,and 53 healthy subjects in the same period were enrolled in this study.Auditory function was evaluated using pure tone audiometry.Totally,type 2 DM group(n=88) and normal control group(NC,n=53) were divided into subgroups based on the presence a... |
| Keywords: | Diabetes mellitus type 2 Hearing impairment Nitric oxide Endothelin-1 |
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